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Inducing vulnerability to InhA inhibition restores isoniazid susceptibility in drug resistant Mycobacterium tuberculosis

Of the approximately 10 million cases of Mycobacterium tuberculosis (Mtb) infections each year, over 10% are resistant to the frontline antibiotic isoniazid (INH). INH resistance is predominantly caused by mutations that decrease the activity of the bacterial enzyme KatG, which mediates conversion o...

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Detalles Bibliográficos
Autores principales:	Harrison, Gregory A., Cho, Kevin, Wang, Erin R., Sarkar, Souvik, Almqvist, Fredrik, Patti, Gary J., Stallings, Christina L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934558/ https://www.ncbi.nlm.nih.gov/pubmed/36798348 http://dx.doi.org/10.1101/2023.02.06.527416

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