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Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core

ALECT2 is a type of systemic amyloidosis caused by deposition of the leukocyte cell-derived chemotaxin-2 (LECT2) protein in the form of fibrils. In ALECT2, LECT2 fibril deposits can be found in the glomerulus, resulting in renal failure. Affected patients lack effective treatment options outside of...

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Detalles Bibliográficos
Autores principales:	Richards, Logan S., Flores, Maria D., Zink, Samantha, Schibrowsky, Natalie A., Sawaya, Michael R., Rodriguez, Jose A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934627/ https://www.ncbi.nlm.nih.gov/pubmed/36798409 http://dx.doi.org/10.1101/2023.02.08.527771

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