Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

Lipids contribute to hematopoiesis and membrane properties and dynamics, however, little is known about the role of lipids in megakaryopoiesis. Here, a lipidomic analysis of megakaryocyte progenitors, megakaryocytes, and platelets revealed a unique lipidome progressively enriched in polyunsaturated...

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Detalles Bibliográficos
Autores principales: Barrachina, Maria N, Pernes, Gerard, Becker, Isabelle C, Allaeys, Isabelle, Hirsch, Thomas I., Groeneveld, Dafna J, Khan, Abdullah O., Freire, Daniela, Guo, Karen, Carminita, Estelle, Morgan, Pooranee K, Collins, Thomas J, Mellett, Natalie A, Wei, Zimu, Almazni, Ibrahim, Italiano, Joseph E., Luyendyk, James, Meikle, Peter J, Puder, Mark, Morgan, Neil V., Boilard, Eric, Murphy, Andrew J, Machlus, Kellie R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934665/
https://www.ncbi.nlm.nih.gov/pubmed/36798332
http://dx.doi.org/10.1101/2023.02.12.527706

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