Chemoproteomic Profiling Reveals that Anti-Cancer Natural Product Dankastatin B Covalently Targets Mitochondrial VDAC3

Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strain Gymnascella dankaliensis have been reported to possess significant anti-cancer activity but their mode of action is unknown. These members possess electrophilic functional groups that may undergo covalent bond formation...

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Detalles Bibliográficos
Autores principales: Belcher, Bridget P., Machicao, Paulo A., Tong, Binqi, Ho, Emily, Friedli, Julia, So, Brian, Bui, Helen, Isobe, Yosuke, Maimone, Thomas J., Nomura, Daniel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934694/
https://www.ncbi.nlm.nih.gov/pubmed/36798342
http://dx.doi.org/10.1101/2023.02.11.528139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934694/
https://www.ncbi.nlm.nih.gov/pubmed/36798342
http://dx.doi.org/10.1101/2023.02.11.528139

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