STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity

STAT3 function in hematopoietic stem and progenitor cells (HSPCs) has been difficult to discern as Stat3 deficiency in the hematopoietic system induces systemic inflammation, which can impact HSPC activity. To address this, we established mixed bone marrow (BM) chimeric mice with CreER-mediated Stat...

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Detalles Bibliográficos
Autores principales: Patel, Bhakti, Zhou, Yifan, Babcock, Rachel L., Ma, Feiyang, Zal, Malgorzata A., Kumar, Dhiraj, Medik, Yusra B., Kahn, Laura M., Pineda, Josué E., Park, Elizabeth M., Tang, Ximing, Raso, Maria Gabriela, Zal, Tomasz, Clise-Dwyer, Karen, Giancotti, Filippo G., Colla, Simona, Watowich, Stephanie S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934695/
https://www.ncbi.nlm.nih.gov/pubmed/36798265
http://dx.doi.org/10.1101/2023.02.10.528069

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