Cargando…

Identification and analysis of individuals who deviate from their genetically-predicted phenotype

Mostrar otras versiones (1)

Findings from genome-wide association studies have facilitated the generation of genetic predictors for many common human phenotypes. Stratifying individuals misaligned to a genetic predictor based on common variants may be important for follow-up studies that aim to identify alternative causal fact...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hawkes, Gareth, Yengo, Loic, Vedantam, Sailaja, Marouli, Eirini, Beaumont, Robin N, Tyrrell, Jessica, Weedon, Michael N, Hirschhorn, Joel, Frayling, Timothy M, Wood, Andrew R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934696/ https://www.ncbi.nlm.nih.gov/pubmed/36798175 http://dx.doi.org/10.1101/2023.02.10.528019

Ejemplares similares

Identification and analysis of individuals who deviate from their genetically-predicted phenotype
por: Hawkes, Gareth, et al.
Publicado: (2023)

Genome-wide CRISPR screening of chondrocyte maturation newly implicates genes in skeletal growth and height-associated GWAS loci
por: Baronas, John M., et al.
Publicado: (2023)

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
por: Pulit, Sara L, et al.
Publicado: (2019)

Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population
por: Kingdom, Rebecca, et al.
Publicado: (2022)

Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records
por: Ruth, Katherine S., et al.
Publicado: (2023)

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
por: Tyrrell, Jessica, et al.
Publicado: (2016)

A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
por: Green, Harry D., et al.
Publicado: (2021)

A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin–creatinine ratio
por: Casanova, Francesco, et al.
Publicado: (2019)

Baseline Metabolomic Profile as Potential Biomarker for Weight Change After Roux-en-Y Gastric Bypass Surgery
por: Thaker, Vidhu V, et al.
Publicado: (2021)

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health
por: Ruth, Katherine S., et al.
Publicado: (2016)

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively
por: Wood, Andrew R., et al.
Publicado: (2016)

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion
por: Hawkes, Gareth, et al.
Publicado: (2023)

Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood
por: Hawkes, Gareth, et al.
Publicado: (2023)

SUN-054 Genetic Studies of Height-Associated Protein Expression Levels in Childhood
por: Fujimoto, Masanobu, et al.
Publicado: (2020)

Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
por: Wright, Caroline F., et al.
Publicado: (2019)

Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study
por: Green, Harry D, et al.
Publicado: (2020)

Mosaic Turner syndrome shows reduced penetrance in an adult population study
por: Tuke, Marcus A., et al.
Publicado: (2018)

Response to Letter to the Editor: “A Genome-Wide Pharmacogenetic Study of Growth Hormone Responsiveness”
por: Hirschhorn, Joel N, et al.
Publicado: (2020)

Genome-Wide Association Study of Microscopic Colitis in the UK Biobank Confirms Immune-Related Pathogenesis
por: Green, Harry D, et al.
Publicado: (2019)

Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study
por: Fussey, Jonathan Mark, et al.
Publicado: (2020)

Mendelian randomization supports a causative effect of TSH on thyroid carcinoma
por: Fussey, Jonathan M, et al.
Publicado: (2020)

RETRACTION: Mendelian randomization supports a causative effect of TSH on thyroid carcinoma
por: Fussey, Jonathan M, et al.
Publicado: (2020)

Reduced penetrance of MODY-associated HNF1A/HNF4A variants but not GCK variants in clinically unselected cohorts
por: Mirshahi, Uyenlinh L, et al.
Publicado: (2022)

Recurrent 17q12 microduplications contribute to renal disease but not diabetes
por: Cannon, Stuart, et al.
Publicado: (2023)

Direct and INdirect effects analysis of Genetic lOci (DINGO): A software package to increase the power of locus discovery in GWAS meta-analyses of perinatal phenotypes and traits influenced by indirect genetic effects
por: Hwang, Liang-Dar, et al.
Publicado: (2023)

Common Variants Show Predicted Polygenic Effects on Height in the Tails of the Distribution, Except in Extremely Short Individuals
por: Chan, Yingleong, et al.
Publicado: (2011)

Genetic predictors of participation in optional components of UK Biobank
por: Tyrrell, Jessica, et al.
Publicado: (2021)

Gene–obesogenic environment interactions in the UK Biobank study
por: Tyrrell, Jessica, et al.
Publicado: (2017)

The impact of Mendelian sleep and circadian genetic variants in a population setting
por: Weedon, Michael N., et al.
Publicado: (2022)

Phenotyping the Preterm Brain: Characterizing Individual Deviations From Normative Volumetric Development in Two Large Infant Cohorts
por: Dimitrova, Ralica, et al.
Publicado: (2021)

Genetically proxied therapeutic prolyl-hydroxylase inhibition and cardiovascular risk
por: Harlow, Charli E, et al.
Publicado: (2022)

Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals
por: Kemper, Kathryn E., et al.
Publicado: (2021)

Using genetics to understand the causal influence of higher BMI on depression
por: Tyrrell, Jessica, et al.
Publicado: (2019)

Higher adiposity and mental health: causal inference using Mendelian randomization
por: Casanova, Francesco, et al.
Publicado: (2021)

The Differentiation of Narrative Styles in Individuals with High Psychopathic Deviate
por: Gawda, Barbara
Publicado: (2021)

Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
por: Jones, Samuel E., et al.
Publicado: (2016)

Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study
por: Tyrrell, Jessica S, et al.
Publicado: (2013)

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers
por: Pilling, Luke C., et al.
Publicado: (2017)

Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank
por: Howe, Laura D, et al.
Publicado: (2019)

Mod-ϕ convergence: normality zones and precise deviations
por: Féray, Valentin, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_s8rlbo5d1dn6rp669p7q41rpdq