Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion

Determining how high body-mass index (BMI) at different time points influences the risk of developing type two diabetes (T2D), and affects insulin secretion and insulin sensitivity, is critical. By estimating childhood BMI in 441,761 individuals in the UK Biobank, we identified which genetic variant...

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Detalles Bibliográficos
Autores principales: Hawkes, Gareth, Beaumont, Robin N, Tyrrell, Jessica, Power, Grace M, Wood, Andrew, Laakso, Markku, Silva, Lilian Fernandes, Boehnke, Michael, Yin, Xianyong, Richardson, Tom G, Smith, George Davey, Frayling, Timothy M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934707/
https://www.ncbi.nlm.nih.gov/pubmed/36798216
http://dx.doi.org/10.1101/2023.02.03.23285420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934707/
https://www.ncbi.nlm.nih.gov/pubmed/36798216
http://dx.doi.org/10.1101/2023.02.03.23285420

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