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Heterogeneity in Preclinical Alzheimer’s Disease Trial Cohort Identified by Image-based Data-Driven Disease Progression Modelling

IMPORTANCE: Undetected biological heterogeneity adversely impacts trials in Alzheimer’s disease because rate of cognitive decline — and perhaps response to treatment — differs in subgroups. Recent results show that data-driven approaches can unravel the heterogeneity of Alzheimer’s disease progressi...

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Detalles Bibliográficos
Autores principales:	Shand, Cameron, Markiewicz, Pawel J., Cash, David M., Alexander, Daniel C., Donohue, Michael C., Barkhof, Frederik, Oxtoby, Neil P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934776/ https://www.ncbi.nlm.nih.gov/pubmed/36798314 http://dx.doi.org/10.1101/2023.02.07.23285572

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