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Altered IL-6 signalling and risk of tuberculosis disease: a meta-analysis and Mendelian randomisation study

IL-6 responses are ubiquitous in Mycobacterium tuberculosis (Mtb) infections, but their role in determining human tuberculosis (TB) disease risk is unknown. We used single nucleotide polymorphisms (SNPs) in and near the IL-6 receptor (IL6R) gene, focusing on the non-synonymous variant, rs2228145, as...

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Detalles Bibliográficos
Autores principales:	Hamilton, Fergus, Schurz, Haiko, Yates, Tom A., Gilchrist, James J., Möller, Marlo, Naranbhai, Vivek, Ghazal, Peter, Timpson, Nicholas J, Parks, Tom, Pollara, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934798/ https://www.ncbi.nlm.nih.gov/pubmed/36798349 http://dx.doi.org/10.1101/2023.02.07.23285472

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