MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state

Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the MS4A locus (rs1582763: protective and rs6591561: risk) and serve as major regulators of CSF sTREM2 levels. To understand their...

Descripción completa

Detalles Bibliográficos
Autores principales: You, Shih-Feng, Brase, Logan, Filipello, Fabia, Iyer, Abhirami K., Del-Aguila, Jorge, He, June, D’Oliveira Albanus, Ricardo, Budde, John, Norton, Joanne, Gentsch, Jen, Dräger, Nina M., Sattler, Sydney M., Kampmann, Martin, Piccio, Laura, Morris, John C., Perrin, Richard J., McDade, Eric, Paul, Steven M., Cashikar, Anil G., Benitez, Bruno A., Harari, Oscar, Karch, Celeste M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934804/
https://www.ncbi.nlm.nih.gov/pubmed/36798226
http://dx.doi.org/10.1101/2023.02.06.23285545

Ejemplares similares

Ejemplares similares