Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic–Epigenetic Cross-Talk

Hematopoiesis integrates cytokine signaling, metabolism, and epigenetic modifications to regulate blood cell generation. These processes are linked, as metabolites provide essential substrates for epigenetic marks. In this study, we demonstrate that ATP citrate lyase (Acly), which metabolizes citrat...

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Detalles Bibliográficos
Autores principales: Greenwood, Dalton L., Ramsey, Haley E., Nguyen, Phuong T. T., Patterson, Andrew R., Voss, Kelsey, Bader, Jackie E., Sugiura, Ayaka, Bacigalupa, Zachary A., Schaefer, Samuel, Ye, Xiang, Dahunsi, Debolanle O., Madden, Matthew Z., Wellen, Kathryn E., Savona, Michael R., Ferrell, P. Brent, Rathmell, Jeffrey C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935084/
https://www.ncbi.nlm.nih.gov/pubmed/36547387
http://dx.doi.org/10.4049/immunohorizons.2200086

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