Sorting nexin-dependent therapeutic targeting of oncogenic epidermal growth factor receptor

Overexpression and/or overactivation of the Epidermal Growth Factor Receptor (EGFR) is oncogenic in several tumor types yet targeting the kinase domain of wildtype EGFR has had limited success. EGFR has numerous kinase-independent roles, one of which is accomplished through the Sorting Nexin-depende...

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Detalles Bibliográficos
Autores principales: Atwell, Benjamin, Chen, Cheng-Yu, Christofferson, Matthew, Montfort, William R., Schroeder, Joyce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935382/
https://www.ncbi.nlm.nih.gov/pubmed/36253541
http://dx.doi.org/10.1038/s41417-022-00541-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935382/
https://www.ncbi.nlm.nih.gov/pubmed/36253541
http://dx.doi.org/10.1038/s41417-022-00541-7

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