Cargando…
Significance of HLA in the development of Graves’ orbitopathy
Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. No such correlation was demonstrated for Graves’ orbitopathy (GO) in Caucasian population. HLA-A, -B, -C, -DQ...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935388/ https://www.ncbi.nlm.nih.gov/pubmed/36639701 http://dx.doi.org/10.1038/s41435-023-00193-z |
_version_ | 1784890018588786688 |
---|---|
author | Stasiak, Magdalena Zawadzka-Starczewska, Katarzyna Tymoniuk, Bogusław Stasiak, Bartłomiej Lewiński, Andrzej |
author_facet | Stasiak, Magdalena Zawadzka-Starczewska, Katarzyna Tymoniuk, Bogusław Stasiak, Bartłomiej Lewiński, Andrzej |
author_sort | Stasiak, Magdalena |
collection | PubMed |
description | Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. No such correlation was demonstrated for Graves’ orbitopathy (GO) in Caucasian population. HLA-A, -B, -C, -DQB1 and -DRB1 genotyping was performed using a high-resolution method in a total number of 2378 persons including 70 patients with GO, 91 patients with non-GO GD and 2217 healthy controls to compare allele frequencies between GO, non-GO and controls. Significant associations between GO and HLA profile were demonstrated, with HLA-A*01:01, -A*32:01, -B*37:01, -B*39:01, -B*42:01, -C*08:02, C*03:02, DRB1*03:01, DRB1*14:01 and DQB1*02:01 being genetic markers of increased risk of GO, and HLA-C*04:01, -C*03:04, -C*07:02 and -DRB1*15:02 being protective alleles. Moreover, correlations between HLA alleles and increased or decreased risk of non-GO GD, but with no impact on risk of GO development, were revealed. Identification of these groups of GO-related and GO-protective alleles, as well as the alleles strongly related to non-GO GD, constitutes an important step in a development of personalized medicine, with individual risk assessment and patient-tailored treatment. |
format | Online Article Text |
id | pubmed-9935388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99353882023-02-18 Significance of HLA in the development of Graves’ orbitopathy Stasiak, Magdalena Zawadzka-Starczewska, Katarzyna Tymoniuk, Bogusław Stasiak, Bartłomiej Lewiński, Andrzej Genes Immun Article Graves’ disease (GD), similarly to most autoimmune disease, is triggered by environmental factors in genetically predisposed individuals. Particular HLA alleles increase or decrease GD risk. No such correlation was demonstrated for Graves’ orbitopathy (GO) in Caucasian population. HLA-A, -B, -C, -DQB1 and -DRB1 genotyping was performed using a high-resolution method in a total number of 2378 persons including 70 patients with GO, 91 patients with non-GO GD and 2217 healthy controls to compare allele frequencies between GO, non-GO and controls. Significant associations between GO and HLA profile were demonstrated, with HLA-A*01:01, -A*32:01, -B*37:01, -B*39:01, -B*42:01, -C*08:02, C*03:02, DRB1*03:01, DRB1*14:01 and DQB1*02:01 being genetic markers of increased risk of GO, and HLA-C*04:01, -C*03:04, -C*07:02 and -DRB1*15:02 being protective alleles. Moreover, correlations between HLA alleles and increased or decreased risk of non-GO GD, but with no impact on risk of GO development, were revealed. Identification of these groups of GO-related and GO-protective alleles, as well as the alleles strongly related to non-GO GD, constitutes an important step in a development of personalized medicine, with individual risk assessment and patient-tailored treatment. Nature Publishing Group UK 2023-01-13 2023 /pmc/articles/PMC9935388/ /pubmed/36639701 http://dx.doi.org/10.1038/s41435-023-00193-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Stasiak, Magdalena Zawadzka-Starczewska, Katarzyna Tymoniuk, Bogusław Stasiak, Bartłomiej Lewiński, Andrzej Significance of HLA in the development of Graves’ orbitopathy |
title | Significance of HLA in the development of Graves’ orbitopathy |
title_full | Significance of HLA in the development of Graves’ orbitopathy |
title_fullStr | Significance of HLA in the development of Graves’ orbitopathy |
title_full_unstemmed | Significance of HLA in the development of Graves’ orbitopathy |
title_short | Significance of HLA in the development of Graves’ orbitopathy |
title_sort | significance of hla in the development of graves’ orbitopathy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935388/ https://www.ncbi.nlm.nih.gov/pubmed/36639701 http://dx.doi.org/10.1038/s41435-023-00193-z |
work_keys_str_mv | AT stasiakmagdalena significanceofhlainthedevelopmentofgravesorbitopathy AT zawadzkastarczewskakatarzyna significanceofhlainthedevelopmentofgravesorbitopathy AT tymoniukbogusław significanceofhlainthedevelopmentofgravesorbitopathy AT stasiakbartłomiej significanceofhlainthedevelopmentofgravesorbitopathy AT lewinskiandrzej significanceofhlainthedevelopmentofgravesorbitopathy |