Cargando…

Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention

The objective of this work was to investigate whether impaired insulin secretion can be restored by lifestyle intervention in specific subphenotypes of prediabetes. We assigned 1,045 participants from the Prediabetes Lifestyle Intervention Study (PLIS) to six recently established prediabetes cluster...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wagner, Robert, Heni, Martin, Kantartzis, Konstantinos, Sandforth, Arvid, Machann, Jürgen, Schick, Fritz, Peter, Andreas, Fritsche, Louise, Szendrödi, Julia, Pfeiffer, Andreas F.H., Schürmann, Annette, Blüher, Matthias, Hauner, Hans, Seissler, Jochen, Bornstein, Stefan, Roden, Michael, Stefan, Norbert, Birkenfeld, Andreas L., White, Morris F., Häring, Hans-Ulrich, Fritsche, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2023
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935494/ https://www.ncbi.nlm.nih.gov/pubmed/36525512 http://dx.doi.org/10.2337/db22-0441

Ejemplares similares

Free fatty acids, glicentin and glucose-dependent insulinotropic polypeptide as potential major determinants of fasting substrate oxidation
por: Hummel, Julia, et al.
Publicado: (2021)

Identification of MicroRNAs Associated with Prediabetic Status in Obese Women
por: Kovac, Leona, et al.
Publicado: (2023)

Normalized Indices Derived from Visceral Adipose Mass Assessed by Magnetic Resonance Imaging and Their Correlation with Markers for Insulin Resistance and Prediabetes
por: Machann, Jürgen, et al.
Publicado: (2020)

Hemostatic alterations linked to body fat distribution, fatty liver, and insulin resistance
por: Hörber, Sebastian, et al.
Publicado: (2021)

Relationships of Circulating Sex Hormone–Binding Globulin With Metabolic Traits in Humans
por: Peter, Andreas, et al.
Publicado: (2010)

Cholesterol Synthesis Is Associated with Hepatic Lipid Content and Dependent on Fructose/Glucose Intake in Healthy Humans
por: Silbernagel, Guenther, et al.
Publicado: (2012)

Dissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
por: Kantartzis, Konstantinos, et al.
Publicado: (2009)

The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design
por: Fritsche, Louise, et al.
Publicado: (2022)

Editorial: Intermittent Fasting – Mechanisms and Clinical Usefulness
por: Fritsche, Andreas, et al.
Publicado: (2021)

Extracellular Matrix Expression in Human Pancreatic Fat Cells of Patients with Normal Glucose Regulation, Prediabetes and Type 2 Diabetes
por: Siegel-Axel, Dorothea, et al.
Publicado: (2023)

No modulation of postprandial metabolism by transcutaneous auricular vagus nerve stimulation: a cross-over study in 15 healthy men
por: Vosseler, Andreas, et al.
Publicado: (2020)

Circulating Palmitoleate Strongly and Independently Predicts Insulin Sensitivity in Humans
por: Stefan, Norbert, et al.
Publicado: (2010)

Dietary Niacin Intake Predicts the Decrease of Liver Fat Content During a Lifestyle Intervention
por: Linder, Katarzyna, et al.
Publicado: (2019)

Sex differences in central insulin action: Effect of intranasal insulin on neural food cue reactivity in adults with normal weight and overweight
por: Wagner, Lore, et al.
Publicado: (2022)

Detection of diabetes from whole-body MRI using deep learning
por: Dietz, Benedikt, et al.
Publicado: (2021)

Novel Meta-Analysis-Derived Type 2 Diabetes Risk Loci Do Not Determine Prediabetic Phenotypes
por: Staiger, Harald, et al.
Publicado: (2008)

Single Nucleotide Polymorphisms in the G-Protein Coupled Receptor Kinase 5 (GRK5) Gene are associated with Plasma LDL-Cholesterol Levels in Humans
por: Lutz, Stefan Z., et al.
Publicado: (2018)

Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health
por: Wagner, Robert, et al.
Publicado: (2022)

Low-Density Lipoprotein Cholesterol Is Associated With Insulin Secretion
por: Dannecker, Corinna, et al.
Publicado: (2021)

Reduced cortical thickness associated with visceral fat and BMI
por: Veit, Ralf, et al.
Publicado: (2014)

Glucose-Raising Polymorphisms in the Human Clock Gene Cryptochrome 2 (CRY2) Affect Hepatic Lipid Content
por: Machicao, Fausto, et al.
Publicado: (2016)

Considering Insulin Secretory Capacity as Measured by a Fasting C-Peptide/Glucose Ratio in Selecting Glucose-Lowering Medications
por: Fritsche, Andreas, et al.
Publicado: (2020)

Common Genetic Variation in the SERPINF1 Locus Determines Overall Adiposity, Obesity-Related Insulin Resistance, and Circulating Leptin Levels
por: Böhm, Anja, et al.
Publicado: (2012)

Diabetes and the Prostate: Elevated Fasting Glucose, Insulin Resistance and Higher Levels of Adrenal Steroids in Prostate Cancer
por: Lutz, Stefan Zoltán, et al.
Publicado: (2022)

Intranasal insulin enhances brain functional connectivity mediating the relationship between adiposity and subjective feeling of hunger
por: Kullmann, Stephanie, et al.
Publicado: (2017)

SIRT1 genetic variants associate with the metabolic response of Caucasians to a controlled lifestyle intervention – the TULIP Study
por: Weyrich, Peter, et al.
Publicado: (2008)

Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase
por: Hummel, Julia, et al.
Publicado: (2023)

Gene Variants of TCF7L2 Influence Weight Loss and Body Composition During Lifestyle Intervention in a Population at Risk for Type 2 Diabetes
por: Haupt, Axel, et al.
Publicado: (2010)

Maternal Weight Gain during Pregnancy and the Developing Autonomic Nervous System—Possible Impact of GDM
por: Fritsche, Louise, et al.
Publicado: (2022)

Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese
por: Kullmann, Stephanie, et al.
Publicado: (2022)

No association between variation in the NR4A1 gene locus and metabolic traits in white subjects at increased risk for type 2 diabetes
por: Müssig, Karsten, et al.
Publicado: (2010)

Common Genetic Variation in the Human CTF1 Locus, Encoding Cardiotrophin-1, Determines Insulin Sensitivity
por: Lutz, Stefan Z., et al.
Publicado: (2014)

FTO Genotype Interacts with Improvement in Aerobic Fitness on Body Weight Loss During Lifestyle Intervention
por: Sailer, Corinna, et al.
Publicado: (2016)

Evaluation of Fasting State-/Oral Glucose Tolerance Test-Derived Measures of Insulin Release for the Detection of Genetically Impaired β-Cell Function
por: Herzberg-Schäfer, Silke A., et al.
Publicado: (2010)

Brain insulin sensitivity is linked to adiposity and body fat distribution
por: Kullmann, Stephanie, et al.
Publicado: (2020)

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
por: Staiger, Harald, et al.
Publicado: (2009)

Reproducibility and discrimination of different indices of insulin sensitivity and insulin secretion
por: Hudak, Sarah, et al.
Publicado: (2021)

Reduced insulin clearance is linked to subclinical atherosclerosis in individuals at risk for type 2 diabetes mellitus
por: Randrianarisoa, Elko, et al.
Publicado: (2020)

Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics
por: Prystupa, Katsiaryna, et al.
Publicado: (2023)

Gene x Gene Interactions Highlight the Role of Incretin Resistance for Insulin Secretion
por: Jaghutriz, Benjamin Assad, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_u06u3bpn0bgavkgjjsad6goj47