Nanodrug rescues liver fibrosis via synergistic therapy with H(2)O(2) depletion and Saikosaponin b1 sustained release

Hypoxia and hydrogen peroxide (H(2)O(2)) accumulation form the profibrogenic liver environment, which involves fibrogenesis and chronic stimulation of hepatic stellate cells (HSCs). Catalase (CAT) is the major antioxidant enzyme that catalyzes H(2)O(2) into oxygen and water, which loses its activity...

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Detalles Bibliográficos
Autores principales: Peng, Mengyun, Shao, Meiyu, Dong, Hongyan, Han, Xin, Hao, Min, Yang, Qiao, Lyu, Qiang, Tang, Dongxin, Shen, Zhe, Wang, Kuilong, Kuang, Haodan, Cao, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935535/
https://www.ncbi.nlm.nih.gov/pubmed/36797395
http://dx.doi.org/10.1038/s42003-023-04473-2

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