Semi-synthetic terpenoids with differential adjuvant properties as sustainable replacements for shark squalene in vaccine emulsions

Synthetic biology has allowed for the industrial production of supply-limited sesquiterpenoids such as the antimalarial drug artemisinin and β-farnesene. One of the only unmodified animal products used in medicine is squalene, a triterpenoid derived from shark liver oil, which when formulated into a...

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Detalles Bibliográficos
Autores principales: Fisher, Karl J., Kinsey, Robert, Mohamath, Raodoh, Phan, Tony, Liang, Hong, Orr, Mark T., Lykins, William R., Guderian, Jeffrey A., Bakken, Julie, Argilla, David, Ramer-Denisoff, Gabi, Larson, Elise, Qi, Yizhi, Sivananthan, Sandra, Smolyar, Karina, Carter, Darrick, Paddon, Christopher J., Fox, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935550/
https://www.ncbi.nlm.nih.gov/pubmed/36797262
http://dx.doi.org/10.1038/s41541-023-00608-y

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