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Protein arginine methyltransferases in renal development, injury, repair, and fibrosis
Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935595/ https://www.ncbi.nlm.nih.gov/pubmed/36817133 http://dx.doi.org/10.3389/fphar.2023.1123415 |
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author | Yu, Jianjun Yu, Chao Bayliss, Georgia Zhuang, Shougang |
author_facet | Yu, Jianjun Yu, Chao Bayliss, Georgia Zhuang, Shougang |
author_sort | Yu, Jianjun |
collection | PubMed |
description | Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications. |
format | Online Article Text |
id | pubmed-9935595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99355952023-02-18 Protein arginine methyltransferases in renal development, injury, repair, and fibrosis Yu, Jianjun Yu, Chao Bayliss, Georgia Zhuang, Shougang Front Pharmacol Pharmacology Protein arginine methyltransferases (PRMTs) methylate a range of histone and non-histone substrates and participate in multiple biological processes by regulating gene transcription and post-translational modifications. To date, most studies on PRMTs have focused on their roles in tumors and in the physiological and pathological conditions of other organs. Emerging evidence indicates that PRMTs are expressed in the kidney and contribute to renal development, injury, repair, and fibrosis. In this review, we summarize the role and the mechanisms of PRMTs in regulating these renal processes and provide a perspective for future clinical applications. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9935595/ /pubmed/36817133 http://dx.doi.org/10.3389/fphar.2023.1123415 Text en Copyright © 2023 Yu, Yu, Bayliss and Zhuang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Yu, Jianjun Yu, Chao Bayliss, Georgia Zhuang, Shougang Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title | Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title_full | Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title_fullStr | Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title_full_unstemmed | Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title_short | Protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
title_sort | protein arginine methyltransferases in renal development, injury, repair, and fibrosis |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935595/ https://www.ncbi.nlm.nih.gov/pubmed/36817133 http://dx.doi.org/10.3389/fphar.2023.1123415 |
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