Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus

Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading to the release of DNA from cells remain poorly characterized. Here, we show that the pore-forming protein, gasdermin D (GSDMD), is required for nuclear...

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Detalles Bibliográficos
Autores principales: Miao, Naijun, Wang, Zhuning, Wang, Qinlan, Xie, Hongyan, Yang, Ninghao, Wang, Yanzhe, Wang, Jin, Kang, Haixia, Bai, Wenjuan, Wang, Yuanyuan, He, Rui, Yan, Kepeng, Wang, Yang, Hu, Qiongyi, Liu, Zhaoyuan, Li, Fubin, Wang, Feng, Ginhoux, Florent, Zhang, Xiaoling, Yin, Jianyong, Lu, Limin, Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935630/
https://www.ncbi.nlm.nih.gov/pubmed/36797275
http://dx.doi.org/10.1038/s41467-023-36522-z

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