The ULK3 kinase is a determinant of keratinocyte self-renewal and tumorigenesis targeting the arginine methylome

Epigenetic mechanisms oversee epidermal homeostasis and oncogenesis. The identification of kinases controlling these processes has direct therapeutic implications. We show that ULK3 is a nuclear kinase with elevated expression levels in squamous cell carcinomas (SCCs) arising in multiple body sites,...

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Detalles Bibliográficos
Autores principales: Goruppi, Sandro, Clocchiatti, Andrea, Bottoni, Giulia, Di Cicco, Emery, Ma, Min, Tassone, Beatrice, Neel, Victor, Demehri, Shadhmer, Simon, Christian, Paolo Dotto, G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935893/
https://www.ncbi.nlm.nih.gov/pubmed/36797248
http://dx.doi.org/10.1038/s41467-023-36410-6

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