Regulation of the tumor immune microenvironment by cancer-derived circular RNAs

Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can be released to the surrounding environment and captured by other cell types. This, circRNAs serve as connections between...

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Autores principales: Guan, Liping, Hao, Qian, Shi, Fenfen, Gao, Bo, Wang, Mengxin, Zhou, Xiang, Han, Tao, Ren, Wenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935907/
https://www.ncbi.nlm.nih.gov/pubmed/36797245
http://dx.doi.org/10.1038/s41419-023-05647-w
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author Guan, Liping
Hao, Qian
Shi, Fenfen
Gao, Bo
Wang, Mengxin
Zhou, Xiang
Han, Tao
Ren, Wenjie
author_facet Guan, Liping
Hao, Qian
Shi, Fenfen
Gao, Bo
Wang, Mengxin
Zhou, Xiang
Han, Tao
Ren, Wenjie
author_sort Guan, Liping
collection PubMed
description Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can be released to the surrounding environment and captured by other cell types. This, circRNAs serve as connections between different cell types for the mediation of multiple signaling pathways. CircRNAs reshape the tumor microenvironment (TME), a key factor involved in all stages of cancer development, by regulating epithelial-stromal transformation, tumor vascularization, immune cell function, and inflammatory responses. Immune cells are the most abundant cellular TME components, and they have profound toxicity to cancer cells. This review summarizes circRNA regulation of immune cells, including T cells, natural killer cells, and macrophages; highlights the impact of circRNAs on tumor progression, treatment, and prognosis; and indicates new targets for tumor immunotherapy.
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spelling pubmed-99359072023-02-18 Regulation of the tumor immune microenvironment by cancer-derived circular RNAs Guan, Liping Hao, Qian Shi, Fenfen Gao, Bo Wang, Mengxin Zhou, Xiang Han, Tao Ren, Wenjie Cell Death Dis Review Article Circular RNA (circRNAs) is a covalently closed circular non-coding RNA formed by reverse back-splicing from precursor messenger RNA. It is found widely in eukaryotic cells and can be released to the surrounding environment and captured by other cell types. This, circRNAs serve as connections between different cell types for the mediation of multiple signaling pathways. CircRNAs reshape the tumor microenvironment (TME), a key factor involved in all stages of cancer development, by regulating epithelial-stromal transformation, tumor vascularization, immune cell function, and inflammatory responses. Immune cells are the most abundant cellular TME components, and they have profound toxicity to cancer cells. This review summarizes circRNA regulation of immune cells, including T cells, natural killer cells, and macrophages; highlights the impact of circRNAs on tumor progression, treatment, and prognosis; and indicates new targets for tumor immunotherapy. Nature Publishing Group UK 2023-02-16 /pmc/articles/PMC9935907/ /pubmed/36797245 http://dx.doi.org/10.1038/s41419-023-05647-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Guan, Liping
Hao, Qian
Shi, Fenfen
Gao, Bo
Wang, Mengxin
Zhou, Xiang
Han, Tao
Ren, Wenjie
Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title_full Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title_fullStr Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title_full_unstemmed Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title_short Regulation of the tumor immune microenvironment by cancer-derived circular RNAs
title_sort regulation of the tumor immune microenvironment by cancer-derived circular rnas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935907/
https://www.ncbi.nlm.nih.gov/pubmed/36797245
http://dx.doi.org/10.1038/s41419-023-05647-w
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