DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing

Expanding mitochondrial base editing tools with broad sequence compatibility is of high need for both research and therapeutic purposes. In this study, we identify a DddA homolog from Simiaoa sunii (Ddd_Ss) which can efficiently deaminate cytosine in DC context in double-stranded DNA (dsDNA). We suc...

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Detalles Bibliográficos
Autores principales: Mi, Li, Shi, Ming, Li, Yu-Xuan, Xie, Gang, Rao, Xichen, Wu, Damu, Cheng, Aimin, Niu, Mengxiao, Xu, Fengli, Yu, Ying, Gao, Ning, Wei, Wensheng, Wang, Xianhua, Wang, Yangming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935910/
https://www.ncbi.nlm.nih.gov/pubmed/36797253
http://dx.doi.org/10.1038/s41467-023-36600-2

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