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Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering

Bioinspired strontium magnesium phosphate cements for bone tissue engineering were prepared using a new, facile, environmentally friendly and high yielding (98.5%) precursor method. The bioinspired SMPCs have uniform particle distributions, excellent mechanical strengths and high biocompatibilities....

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Autores principales: Liu, Qiaoyun, Liu, Changjiang, Wang, Weixing, Yuan, Liangjie, Wang, Yu, Yi, Xinzeyu, Pan, Zhenyu, Yu, Aixi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935930/
https://www.ncbi.nlm.nih.gov/pubmed/36815894
http://dx.doi.org/10.3389/fbioe.2023.1142095
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author Liu, Qiaoyun
Liu, Changjiang
Wang, Weixing
Yuan, Liangjie
Wang, Yu
Yi, Xinzeyu
Pan, Zhenyu
Yu, Aixi
author_facet Liu, Qiaoyun
Liu, Changjiang
Wang, Weixing
Yuan, Liangjie
Wang, Yu
Yi, Xinzeyu
Pan, Zhenyu
Yu, Aixi
author_sort Liu, Qiaoyun
collection PubMed
description Bioinspired strontium magnesium phosphate cements for bone tissue engineering were prepared using a new, facile, environmentally friendly and high yielding (98.5%) precursor method. The bioinspired SMPCs have uniform particle distributions, excellent mechanical strengths and high biocompatibilities. The in vitro responses of bone marrow stromal cells to the SMPCs, including viability, osteogenic differentiation and alkaline phosphatase activity, were evaluated. The results show that the SMPC containing 0.5 mol of strontium (referred to as SMPC-2) has a higher degradation rate and biological activity than magnesium phosphate cements and the other SMPCs. In addition, the synergistic effect of strontium and magnesium ion release from SMPC-2 creates a conducive environment for cell proliferation, mineralized calcium deposition and new bone formation. These observations demonstrate the feasibility of using the new precursor method to generate SMPCs and the utility of these biologically compatible and highly effective cements for bone tissue engineering.
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spelling pubmed-99359302023-02-18 Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering Liu, Qiaoyun Liu, Changjiang Wang, Weixing Yuan, Liangjie Wang, Yu Yi, Xinzeyu Pan, Zhenyu Yu, Aixi Front Bioeng Biotechnol Bioengineering and Biotechnology Bioinspired strontium magnesium phosphate cements for bone tissue engineering were prepared using a new, facile, environmentally friendly and high yielding (98.5%) precursor method. The bioinspired SMPCs have uniform particle distributions, excellent mechanical strengths and high biocompatibilities. The in vitro responses of bone marrow stromal cells to the SMPCs, including viability, osteogenic differentiation and alkaline phosphatase activity, were evaluated. The results show that the SMPC containing 0.5 mol of strontium (referred to as SMPC-2) has a higher degradation rate and biological activity than magnesium phosphate cements and the other SMPCs. In addition, the synergistic effect of strontium and magnesium ion release from SMPC-2 creates a conducive environment for cell proliferation, mineralized calcium deposition and new bone formation. These observations demonstrate the feasibility of using the new precursor method to generate SMPCs and the utility of these biologically compatible and highly effective cements for bone tissue engineering. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9935930/ /pubmed/36815894 http://dx.doi.org/10.3389/fbioe.2023.1142095 Text en Copyright © 2023 Liu, Liu, Wang, Yuan, Wang, Yi, Pan and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Liu, Qiaoyun
Liu, Changjiang
Wang, Weixing
Yuan, Liangjie
Wang, Yu
Yi, Xinzeyu
Pan, Zhenyu
Yu, Aixi
Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title_full Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title_fullStr Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title_full_unstemmed Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title_short Bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
title_sort bioinspired strontium magnesium phosphate cement prepared utilizing the precursor method for bone tissue engineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935930/
https://www.ncbi.nlm.nih.gov/pubmed/36815894
http://dx.doi.org/10.3389/fbioe.2023.1142095
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