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Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments

This study examines cortical organoids generated from a panel of isogenic trisomic and disomic iPSC lines (subclones) as a model of early fetal brain development in Down syndrome (DS). An initial experiment comparing organoids from one trisomic and one disomic line showed many genome-wide transcript...

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Detalles Bibliográficos
Autores principales:	Czerminski, Jan T., King, Oliver D., Lawrence, Jeanne B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935940/ https://www.ncbi.nlm.nih.gov/pubmed/36817096 http://dx.doi.org/10.3389/fnins.2022.972201

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