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Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery

Cerebral venous sinus thrombosis (CVST) is a rare, high-risk, and easily misdiagnosed disease. Currently, there are case reports of hem coagulase-induced thrombotic events, but no reports of CVST being associated with hem coagulase. CASE SUMMARY: A 35-years-old woman presented to the outpatient clin...

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Autores principales: Sun, Bei, Liu, Tingting, Xu, Bingchao, Zhang, Guanghui, Xie, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935984/
https://www.ncbi.nlm.nih.gov/pubmed/36800639
http://dx.doi.org/10.1097/MD.0000000000032948
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author Sun, Bei
Liu, Tingting
Xu, Bingchao
Zhang, Guanghui
Xie, Kang
author_facet Sun, Bei
Liu, Tingting
Xu, Bingchao
Zhang, Guanghui
Xie, Kang
author_sort Sun, Bei
collection PubMed
description Cerebral venous sinus thrombosis (CVST) is a rare, high-risk, and easily misdiagnosed disease. Currently, there are case reports of hem coagulase-induced thrombotic events, but no reports of CVST being associated with hem coagulase. CASE SUMMARY: A 35-years-old woman presented to the outpatient clinic with a severe headache and sudden memory loss with intravenous hem coagulase for postoperative bleeding after uterine fibroids surgery. Abnormal neurological signs included slowed reactions, poor memory, and decreased numeracy. Magnetic resonance imaging and computed tomography scan showed multiple cerebral infarcts, and the infarct area was non-arterial. Brain magnetic resonance venography showed obstruction of the left sigmoid sinus. High-resolution magnetic resonance imaging of the left sigmoid sinus showed abnormally high signal. The patient was treated with a subcutaneous Low-Molecular-Weight Heparin Sodium injection 0.4 ml, twice a day (7 days), and oral Warfarin Sodium 3 mg, once a day, while monitoring the international normalized ratio, adjust the warfarin sodium dosage according to the international normalized ratio level. One month later, the patient had no neurological symptoms and her cognitive function returned to normal. CONCLUSION: hem coagulase may be a contributing factor to CVST in patients undergoing uterine fibroids surgery and should be administered intravenously with caution.
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spelling pubmed-99359842023-02-18 Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery Sun, Bei Liu, Tingting Xu, Bingchao Zhang, Guanghui Xie, Kang Medicine (Baltimore) 5300 Cerebral venous sinus thrombosis (CVST) is a rare, high-risk, and easily misdiagnosed disease. Currently, there are case reports of hem coagulase-induced thrombotic events, but no reports of CVST being associated with hem coagulase. CASE SUMMARY: A 35-years-old woman presented to the outpatient clinic with a severe headache and sudden memory loss with intravenous hem coagulase for postoperative bleeding after uterine fibroids surgery. Abnormal neurological signs included slowed reactions, poor memory, and decreased numeracy. Magnetic resonance imaging and computed tomography scan showed multiple cerebral infarcts, and the infarct area was non-arterial. Brain magnetic resonance venography showed obstruction of the left sigmoid sinus. High-resolution magnetic resonance imaging of the left sigmoid sinus showed abnormally high signal. The patient was treated with a subcutaneous Low-Molecular-Weight Heparin Sodium injection 0.4 ml, twice a day (7 days), and oral Warfarin Sodium 3 mg, once a day, while monitoring the international normalized ratio, adjust the warfarin sodium dosage according to the international normalized ratio level. One month later, the patient had no neurological symptoms and her cognitive function returned to normal. CONCLUSION: hem coagulase may be a contributing factor to CVST in patients undergoing uterine fibroids surgery and should be administered intravenously with caution. Lippincott Williams & Wilkins 2023-02-17 /pmc/articles/PMC9935984/ /pubmed/36800639 http://dx.doi.org/10.1097/MD.0000000000032948 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 5300
Sun, Bei
Liu, Tingting
Xu, Bingchao
Zhang, Guanghui
Xie, Kang
Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title_full Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title_fullStr Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title_full_unstemmed Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title_short Hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
title_sort hem coagulase induced cerebral venous sinus thrombosis in patients with uterine fibroids surgery
topic 5300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9935984/
https://www.ncbi.nlm.nih.gov/pubmed/36800639
http://dx.doi.org/10.1097/MD.0000000000032948
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