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Building thalamic neuronal networks during mouse development

The thalamic nuclear complex contains excitatory projection neurons and inhibitory local neurons, the two cell types driving the main circuits in sensory nuclei. While excitatory neurons are born from progenitors that reside in the proliferative zone of the developing thalamus, inhibitory local neur...

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Autores principales: Huerga-Gómez, Irene, Martini, Francisco J., López-Bendito, Guillermina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936079/
https://www.ncbi.nlm.nih.gov/pubmed/36817644
http://dx.doi.org/10.3389/fncir.2023.1098913
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author Huerga-Gómez, Irene
Martini, Francisco J.
López-Bendito, Guillermina
author_facet Huerga-Gómez, Irene
Martini, Francisco J.
López-Bendito, Guillermina
author_sort Huerga-Gómez, Irene
collection PubMed
description The thalamic nuclear complex contains excitatory projection neurons and inhibitory local neurons, the two cell types driving the main circuits in sensory nuclei. While excitatory neurons are born from progenitors that reside in the proliferative zone of the developing thalamus, inhibitory local neurons are born outside the thalamus and they migrate there during development. In addition to these cell types, which occupy most of the thalamus, there are two small thalamic regions where inhibitory neurons target extra-thalamic regions rather than neighboring neurons, the intergeniculate leaflet and the parahabenular nucleus. Like excitatory thalamic neurons, these inhibitory neurons are derived from progenitors residing in the developing thalamus. The assembly of these circuits follows fine-tuned genetic programs and it is coordinated by extrinsic factors that help the cells find their location, associate with thalamic partners, and establish connections with their corresponding extra-thalamic inputs and outputs. In this review, we bring together what is currently known about the development of the excitatory and inhibitory components of the thalamocortical sensory system, in particular focusing on the visual pathway and thalamic interneurons in mice.
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spelling pubmed-99360792023-02-18 Building thalamic neuronal networks during mouse development Huerga-Gómez, Irene Martini, Francisco J. López-Bendito, Guillermina Front Neural Circuits Neural Circuits The thalamic nuclear complex contains excitatory projection neurons and inhibitory local neurons, the two cell types driving the main circuits in sensory nuclei. While excitatory neurons are born from progenitors that reside in the proliferative zone of the developing thalamus, inhibitory local neurons are born outside the thalamus and they migrate there during development. In addition to these cell types, which occupy most of the thalamus, there are two small thalamic regions where inhibitory neurons target extra-thalamic regions rather than neighboring neurons, the intergeniculate leaflet and the parahabenular nucleus. Like excitatory thalamic neurons, these inhibitory neurons are derived from progenitors residing in the developing thalamus. The assembly of these circuits follows fine-tuned genetic programs and it is coordinated by extrinsic factors that help the cells find their location, associate with thalamic partners, and establish connections with their corresponding extra-thalamic inputs and outputs. In this review, we bring together what is currently known about the development of the excitatory and inhibitory components of the thalamocortical sensory system, in particular focusing on the visual pathway and thalamic interneurons in mice. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9936079/ /pubmed/36817644 http://dx.doi.org/10.3389/fncir.2023.1098913 Text en Copyright © 2023 Huerga-Gómez, Martini and López-Bendito. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neural Circuits
Huerga-Gómez, Irene
Martini, Francisco J.
López-Bendito, Guillermina
Building thalamic neuronal networks during mouse development
title Building thalamic neuronal networks during mouse development
title_full Building thalamic neuronal networks during mouse development
title_fullStr Building thalamic neuronal networks during mouse development
title_full_unstemmed Building thalamic neuronal networks during mouse development
title_short Building thalamic neuronal networks during mouse development
title_sort building thalamic neuronal networks during mouse development
topic Neural Circuits
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936079/
https://www.ncbi.nlm.nih.gov/pubmed/36817644
http://dx.doi.org/10.3389/fncir.2023.1098913
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