Metformin attenuates fibroblast activation during pulmonary fibrosis by targeting S100A4 via AMPK-STAT3 axis

Fibroblasts activation is a crucial process for development of fibrosis during idiopathic pulmonary fibrosis pathogenesis, and transforming growth factor (TGF)-β1 plays a key regulatory role in fibroblast activation. It has been reported that metformin (MET) alleviated bleomycin (BLM)-induced pulmon...

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Detalles Bibliográficos
Autores principales: Ji, Huimin, Dong, Hongliang, Lan, Yuejiao, Bi, Yuqian, Gu, Xuan, Han, Yongyue, Yang, Chongyang, Cheng, Minghan, Gao, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936158/
https://www.ncbi.nlm.nih.gov/pubmed/36817136
http://dx.doi.org/10.3389/fphar.2023.1089812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936158/
https://www.ncbi.nlm.nih.gov/pubmed/36817136
http://dx.doi.org/10.3389/fphar.2023.1089812

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