Selective inhibition of integrin αvβ6 leads to rapid induction of urinary bladder tumors in cynomolgus macaques

Administration of a novel and selective small molecule integrin αvβ6 inhibitor, MORF-627, to young cynomolgus monkeys for 28 days resulted in the rapid induction of epithelial proliferative changes in the urinary bladder of 2 animals, in the absence of test agent genotoxicity. Microscopic findings i...

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Detalles Bibliográficos
Autores principales: Guffroy, Magali, Trela, Bruce, Kambara, Takahito, Stawski, Lukasz, Chen, Huidong, Luus, Lia, Montesinos, Monica S, Olson, Lauren, He, Yupeng, Maisonave, Kevin, Carr, Tracy, Lu, Min, Ray, Adrian S, Hazelwood, Lisa A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Organ Specific Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936210/
https://www.ncbi.nlm.nih.gov/pubmed/36515490
http://dx.doi.org/10.1093/toxsci/kfac128

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