IL7 and IL7 Flt3L co-expressing CAR T cells improve therapeutic efficacy in mouse EGFRvIII heterogeneous glioblastoma

Chimeric antigen receptor (CAR) T cell therapy in glioblastoma faces many challenges including insufficient CAR T cell abundance and antigen-negative tumor cells evading targeting. Unfortunately, preclinical studies evaluating CAR T cells in glioblastoma focus on tumor models that express a single a...

Descripción completa

Detalles Bibliográficos
Autores principales: Swan, Sheridan L., Mehta, Nalini, Ilich, Ekaterina, Shen, Steven H., Wilkinson, Daniel S., Anderson, Alexa R., Segura, Tatiana, Sanchez-Perez, Luis, Sampson, John H., Bellamkonda, Ravi V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936235/
https://www.ncbi.nlm.nih.gov/pubmed/36817432
http://dx.doi.org/10.3389/fimmu.2023.1085547

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936235/
https://www.ncbi.nlm.nih.gov/pubmed/36817432
http://dx.doi.org/10.3389/fimmu.2023.1085547

Ejemplares similares