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Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota

Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which ar...

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Autores principales: Shen, Xin, Xu, Lin, Zhang, Zhiquan, Yang, Yitong, Li, Pengxian, Ma, Teng, Guo, Shuai, Kwok, Lai-Yu, Sun, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936311/
https://www.ncbi.nlm.nih.gov/pubmed/36816588
http://dx.doi.org/10.3389/fcimb.2023.1114364
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author Shen, Xin
Xu, Lin
Zhang, Zhiquan
Yang, Yitong
Li, Pengxian
Ma, Teng
Guo, Shuai
Kwok, Lai-Yu
Sun, Zhihong
author_facet Shen, Xin
Xu, Lin
Zhang, Zhiquan
Yang, Yitong
Li, Pengxian
Ma, Teng
Guo, Shuai
Kwok, Lai-Yu
Sun, Zhihong
author_sort Shen, Xin
collection PubMed
description Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which are important for maintaining vaginal health. At present, antibiotics and other drugs are often used in clinical treatment, but there are many adverse reactions and easy to relapse, and the intervention of probiotics can help restore vaginal microbiota and alleviate BV. This study is a human clinical trial of 50 patients with bacterial vaginitis (BV). The alleviation effect of applying a postbiotic gel for one week in BV was evaluated. Changes in patients’ clinical indicators of BV (properties of vaginal secretion) and the vaginal microbiota after using the postbiotic gel were monitored. Our results showed that apply the postbiotic gel improved the symptoms of BV, indicated by improvement in the abnormalities of patients’ vaginal secretions. After applying the gel, the relative abundance of vaginal lactobacilli increased compared to baseline. Significant negative correlations were found between lactobacilli and potential vaginal pathogens (including Gardnerella, Prevotella, and Atopobium), as well as the abnormalities of the vaginal secretion. Overall, our results showed that applying the postbiotic gel ameliorated BV, and the symptom improvement was accompanied by significant changes in the bacterial vaginal microbiota. Our study provides valuable clinical data in managing BV.
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spelling pubmed-99363112023-02-18 Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota Shen, Xin Xu, Lin Zhang, Zhiquan Yang, Yitong Li, Pengxian Ma, Teng Guo, Shuai Kwok, Lai-Yu Sun, Zhihong Front Cell Infect Microbiol Cellular and Infection Microbiology Vaginitis is the most common disease in gynecology. Vaginal dysbiosis is a main reason of bacteria vaginitis (BV), as the disrupted microecological environment facilitates the growth of various vaginal pathogens. The most dominant bacteria in the vaginal microbiota are lactic acid bacteria, which are important for maintaining vaginal health. At present, antibiotics and other drugs are often used in clinical treatment, but there are many adverse reactions and easy to relapse, and the intervention of probiotics can help restore vaginal microbiota and alleviate BV. This study is a human clinical trial of 50 patients with bacterial vaginitis (BV). The alleviation effect of applying a postbiotic gel for one week in BV was evaluated. Changes in patients’ clinical indicators of BV (properties of vaginal secretion) and the vaginal microbiota after using the postbiotic gel were monitored. Our results showed that apply the postbiotic gel improved the symptoms of BV, indicated by improvement in the abnormalities of patients’ vaginal secretions. After applying the gel, the relative abundance of vaginal lactobacilli increased compared to baseline. Significant negative correlations were found between lactobacilli and potential vaginal pathogens (including Gardnerella, Prevotella, and Atopobium), as well as the abnormalities of the vaginal secretion. Overall, our results showed that applying the postbiotic gel ameliorated BV, and the symptom improvement was accompanied by significant changes in the bacterial vaginal microbiota. Our study provides valuable clinical data in managing BV. Frontiers Media S.A. 2023-02-02 /pmc/articles/PMC9936311/ /pubmed/36816588 http://dx.doi.org/10.3389/fcimb.2023.1114364 Text en Copyright © 2023 Shen, Xu, Zhang, Yang, Li, Ma, Guo, Kwok and Sun https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Shen, Xin
Xu, Lin
Zhang, Zhiquan
Yang, Yitong
Li, Pengxian
Ma, Teng
Guo, Shuai
Kwok, Lai-Yu
Sun, Zhihong
Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title_full Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title_fullStr Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title_full_unstemmed Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title_short Postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
title_sort postbiotic gel relieves clinical symptoms of bacterial vaginitis by regulating the vaginal microbiota
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936311/
https://www.ncbi.nlm.nih.gov/pubmed/36816588
http://dx.doi.org/10.3389/fcimb.2023.1114364
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