OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression

One of the most abundant DNA lesions induced by Reactive oxygen species (ROS) is 8-oxoG, a highly mutagenic lesion that compromises genetic instability when not efficiently repaired. 8-oxoG is specifically recognized by the DNA-glycosylase OGG1 that excises the base and initiates the Base Excision R...

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Detalles Bibliográficos
Autores principales: Tanushi, Xhaferr, Pinna, Guillaume, Vandamme, Marie, Siberchicot, Capucine, D’Augustin, Ostiane, Di Guilmi, Anne-Marie, Radicella, J. Pablo, Castaing, Bertrand, Smith, Rebecca, Huet, Sebastien, Leteurtre, François, Campalans, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936318/
https://www.ncbi.nlm.nih.gov/pubmed/36819096
http://dx.doi.org/10.3389/fcell.2023.1124960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936318/
https://www.ncbi.nlm.nih.gov/pubmed/36819096
http://dx.doi.org/10.3389/fcell.2023.1124960

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