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PKR induces TGF-β and limits oncolytic immune therapy

BACKGROUND: Mammalian cells have developed multiple intracellular mechanisms to defend against viral infections. These include RNA-activated protein kinase (PKR), cyclic GMP-AMP synthase and stimulation of interferon genes (cGAS-STING) and toll-like receptor-myeloid differentiation primary response...

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Detalles Bibliográficos
Autores principales:	Hong, Bangxing, Sahu, Upasana, Mullarkey, Matthew P, Hong, Evan, Pei, Guangsheng, Yan, Yuanqing, Otani, Yoshihiro, Banasavadi-Siddegowda, Yeshavanth, Fan, Huihui, Zhao, Zhongming, Yu, Jianhua, Caligiuri, Michael A, Kaur, Balveen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2023
Materias:	Oncolytic and Local Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936322/ https://www.ncbi.nlm.nih.gov/pubmed/36796878 http://dx.doi.org/10.1136/jitc-2022-006164

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