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Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936329/ https://www.ncbi.nlm.nih.gov/pubmed/36819098 http://dx.doi.org/10.3389/fcell.2023.1112751 |
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author | Zhang, Fan Yan, Yuanliang Cai, Yuan Liang, Qiuju Liu, Yuanhong Peng, Bi Xu, Zhijie Liu, Wei |
author_facet | Zhang, Fan Yan, Yuanliang Cai, Yuan Liang, Qiuju Liu, Yuanhong Peng, Bi Xu, Zhijie Liu, Wei |
author_sort | Zhang, Fan |
collection | PubMed |
description | Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies. |
format | Online Article Text |
id | pubmed-9936329 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99363292023-02-18 Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications Zhang, Fan Yan, Yuanliang Cai, Yuan Liang, Qiuju Liu, Yuanhong Peng, Bi Xu, Zhijie Liu, Wei Front Cell Dev Biol Cell and Developmental Biology Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9936329/ /pubmed/36819098 http://dx.doi.org/10.3389/fcell.2023.1112751 Text en Copyright © 2023 Zhang, Yan, Cai, Liang, Liu, Peng, Xu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhang, Fan Yan, Yuanliang Cai, Yuan Liang, Qiuju Liu, Yuanhong Peng, Bi Xu, Zhijie Liu, Wei Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title | Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title_full | Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title_fullStr | Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title_full_unstemmed | Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title_short | Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
title_sort | current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936329/ https://www.ncbi.nlm.nih.gov/pubmed/36819098 http://dx.doi.org/10.3389/fcell.2023.1112751 |
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