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Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications

Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in...

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Autores principales: Zhang, Fan, Yan, Yuanliang, Cai, Yuan, Liang, Qiuju, Liu, Yuanhong, Peng, Bi, Xu, Zhijie, Liu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936329/
https://www.ncbi.nlm.nih.gov/pubmed/36819098
http://dx.doi.org/10.3389/fcell.2023.1112751
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author Zhang, Fan
Yan, Yuanliang
Cai, Yuan
Liang, Qiuju
Liu, Yuanhong
Peng, Bi
Xu, Zhijie
Liu, Wei
author_facet Zhang, Fan
Yan, Yuanliang
Cai, Yuan
Liang, Qiuju
Liu, Yuanhong
Peng, Bi
Xu, Zhijie
Liu, Wei
author_sort Zhang, Fan
collection PubMed
description Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies.
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spelling pubmed-99363292023-02-18 Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications Zhang, Fan Yan, Yuanliang Cai, Yuan Liang, Qiuju Liu, Yuanhong Peng, Bi Xu, Zhijie Liu, Wei Front Cell Dev Biol Cell and Developmental Biology Ferroptosis is a novel type of cell death associated with iron accumulation and excessive lipid peroxidation. Elucidating the underlying molecular mechanisms of ferroptosis is intensively related to the development and treatment of multiple diseases, including musculoskeletal disorders. Moreover, in vitro and in vivo studies have shown the importance of oxidative stress in musculoskeletal conditions such as osteoporosis, osteoarthritis, rheumatoid arthritis, and osteosarcoma. Ferroptosis-derived clinical management of musculoskeletal diseases offers tremendous and attractive opportunities. Notably, ferroptosis agonists have been proven to enhance the sensitivity of osteosarcoma cells to conventional therapeutic strategies. In this review, we have mainly focused on the implications of ferroptosis regulation in the pathophysiology and therapeutic response of musculoskeletal disorders. Understanding roles of ferroptosis for controlling musculoskeletal diseases might provide directions for ferroptosis-driven therapies, which could be promising for the development of novel therapeutic strategies. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9936329/ /pubmed/36819098 http://dx.doi.org/10.3389/fcell.2023.1112751 Text en Copyright © 2023 Zhang, Yan, Cai, Liang, Liu, Peng, Xu and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhang, Fan
Yan, Yuanliang
Cai, Yuan
Liang, Qiuju
Liu, Yuanhong
Peng, Bi
Xu, Zhijie
Liu, Wei
Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title_full Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title_fullStr Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title_full_unstemmed Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title_short Current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
title_sort current insights into the functional roles of ferroptosis in musculoskeletal diseases and therapeutic implications
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936329/
https://www.ncbi.nlm.nih.gov/pubmed/36819098
http://dx.doi.org/10.3389/fcell.2023.1112751
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