Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals

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Herein, we studied the impact of empty LNP (eLNP), component of mRNA-based vaccine, on anti-viral pathways and immune function of cells from young and aged individuals. eLNP induced maturation of monocyte derived dendritic cells (MDDCs). We further show that eLNP upregulated CD40 and induced cytokin...

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Detalles Bibliográficos
Autores principales: Connors, Jennifer, Joyner, David, Mege, Nathan J., Cusimano, Gina M., Bell, Matthew R., Marcy, Jennifer, Taramangalam, Bhavani, Kim, Kenneth M., Lin, Paulo J. C., Tam, Ying K., Weissman, Drew, Kutzler, Michele A., Alameh, Mohamad-Gabriel, Haddad, Elias K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936473/
https://www.ncbi.nlm.nih.gov/pubmed/36805684
http://dx.doi.org/10.1038/s42003-023-04555-1

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