Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry

[Image: see text] Electrophiles for covalent inhibitors that are suitable for in vivo administration are rare. While acrylamides are prevalent in FDA-approved covalent drugs, chloroacetamides are considered too reactive for such purposes. We report sulfamate-based electrophiles that maintain chloroa...

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Detalles Bibliográficos
Autores principales: Reddi, Rambabu N., Rogel, Adi, Gabizon, Ronen, Rawale, Dattatraya Gautam, Harish, Battu, Marom, Shir, Tivon, Barr, Arbel, Yamit Shorer, Gurwicz, Neta, Oren, Roni, David, Keren, Liu, Jingjing, Duberstein, Shirly, Itkin, Maxim, Malitsky, Sergey, Barr, Haim, Katz, Ben-Zion, Herishanu, Yair, Shachar, Idit, Shulman, Ziv, London, Nir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936582/
https://www.ncbi.nlm.nih.gov/pubmed/36738297
http://dx.doi.org/10.1021/jacs.2c08853

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