Long non-coding RNA signature in colorectal cancer: research progression and clinical application

Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expr...

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Autores principales: Wu, Yudi, Xu, Xiangshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936661/
https://www.ncbi.nlm.nih.gov/pubmed/36797749
http://dx.doi.org/10.1186/s12935-023-02867-0
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author Wu, Yudi
Xu, Xiangshang
author_facet Wu, Yudi
Xu, Xiangshang
author_sort Wu, Yudi
collection PubMed
description Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expression. Numerous current studies have shown that lncRNAs are promising biomarkers and therapeutic targets for colorectal cancer. In this review, we have searched the available literature to list lncRNAs involved in the pathogenesis and regulation of colorectal cancer. We focus on the role of lncRNAs in cancer promotion or suppression, their value in tumor diagnosis, and their role in treatment response and prognosis prediction. In addition, we will discuss the signaling pathways that these lncRNAs are mainly associated with in colorectal cancer. We also summarize the role of lncRNAs in colorectal precancerous lesions and colorectal cancer consensus molecular subgroups. We hope this review article will bring you the latest research progress and outlook on lncRNAs in colorectal cancer.
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spelling pubmed-99366612023-02-18 Long non-coding RNA signature in colorectal cancer: research progression and clinical application Wu, Yudi Xu, Xiangshang Cancer Cell Int Review Colorectal cancer is one of the top-ranked human malignancies. The development and progression of colorectal cancer are associated with aberrant expression of multiple coding and non-coding genes. Long non-coding RNAs (lncRNAs) have an important role in regulating gene stability as well as gene expression. Numerous current studies have shown that lncRNAs are promising biomarkers and therapeutic targets for colorectal cancer. In this review, we have searched the available literature to list lncRNAs involved in the pathogenesis and regulation of colorectal cancer. We focus on the role of lncRNAs in cancer promotion or suppression, their value in tumor diagnosis, and their role in treatment response and prognosis prediction. In addition, we will discuss the signaling pathways that these lncRNAs are mainly associated with in colorectal cancer. We also summarize the role of lncRNAs in colorectal precancerous lesions and colorectal cancer consensus molecular subgroups. We hope this review article will bring you the latest research progress and outlook on lncRNAs in colorectal cancer. BioMed Central 2023-02-16 /pmc/articles/PMC9936661/ /pubmed/36797749 http://dx.doi.org/10.1186/s12935-023-02867-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Wu, Yudi
Xu, Xiangshang
Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title_full Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title_fullStr Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title_full_unstemmed Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title_short Long non-coding RNA signature in colorectal cancer: research progression and clinical application
title_sort long non-coding rna signature in colorectal cancer: research progression and clinical application
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936661/
https://www.ncbi.nlm.nih.gov/pubmed/36797749
http://dx.doi.org/10.1186/s12935-023-02867-0
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