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Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study
INTRODUCTION: Postural control deficits are a potential cause of persistent and recurrent pain in patients with chronic low back pain (CLBP). Although some studies have confirmed that the dorsolateral prefrontal cortex (DLPFC) contributes to pain regulation in CLBP, its role in the postural control...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936824/ https://www.ncbi.nlm.nih.gov/pubmed/36816497 http://dx.doi.org/10.3389/fnhum.2023.1085831 |
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author | Li, Yan Xu, Zhaoqiang Xie, Hao Fu, Ruochen Lo, Wai Leung Ambrose Cheng, Xue Yang, Jiajia Ge, Le Yu, Quihua Wang, Chuhuai |
author_facet | Li, Yan Xu, Zhaoqiang Xie, Hao Fu, Ruochen Lo, Wai Leung Ambrose Cheng, Xue Yang, Jiajia Ge, Le Yu, Quihua Wang, Chuhuai |
author_sort | Li, Yan |
collection | PubMed |
description | INTRODUCTION: Postural control deficits are a potential cause of persistent and recurrent pain in patients with chronic low back pain (CLBP). Although some studies have confirmed that the dorsolateral prefrontal cortex (DLPFC) contributes to pain regulation in CLBP, its role in the postural control of patients with CLBP remains unclear. Therefore, this study aimed to investigate the DLPFC activation of patients with CLBP and healthy controls under different upright stance task conditions. METHODS: Twenty patients with CLBP (26.50 ± 2.48 years) and 20 healthy controls (25.75 ± 3.57 years) performed upright stance tasks under three conditions: Task-1 was static balance with eyes open; Task-2 was static balance with eyes closed; Task-3 involved dynamic balance on an unstable surface with eyes open. A wireless functional near-infrared spectroscopy (fNIRS) system measured cortical activity, including the bilateral DLPFC, pre-motor cortex (PMC) and supplementary motor area (SMA), the primary motor cortex (M1), the primary somatosensory cortex (S1), and a force platform measured balance parameters during upright stance. RESULTS: The two-way repeated measures ANOVA results showed significant interaction in bilateral PMC/SMA activation. Moreover, patients with CLBP had significantly increased right DLPFC activation and higher sway 32 area and velocity than healthy controls during upright stance. DISCUSSION: Our results imply that PMC/SMA and DLPFC maintain standing balance. The patients with CLBP have higher cortical activity and upright stance control deficits, which may indicate that the patients with CLBP have low neural efficiency and need more motor resources to maintain balance. |
format | Online Article Text |
id | pubmed-9936824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99368242023-02-18 Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study Li, Yan Xu, Zhaoqiang Xie, Hao Fu, Ruochen Lo, Wai Leung Ambrose Cheng, Xue Yang, Jiajia Ge, Le Yu, Quihua Wang, Chuhuai Front Hum Neurosci Neuroscience INTRODUCTION: Postural control deficits are a potential cause of persistent and recurrent pain in patients with chronic low back pain (CLBP). Although some studies have confirmed that the dorsolateral prefrontal cortex (DLPFC) contributes to pain regulation in CLBP, its role in the postural control of patients with CLBP remains unclear. Therefore, this study aimed to investigate the DLPFC activation of patients with CLBP and healthy controls under different upright stance task conditions. METHODS: Twenty patients with CLBP (26.50 ± 2.48 years) and 20 healthy controls (25.75 ± 3.57 years) performed upright stance tasks under three conditions: Task-1 was static balance with eyes open; Task-2 was static balance with eyes closed; Task-3 involved dynamic balance on an unstable surface with eyes open. A wireless functional near-infrared spectroscopy (fNIRS) system measured cortical activity, including the bilateral DLPFC, pre-motor cortex (PMC) and supplementary motor area (SMA), the primary motor cortex (M1), the primary somatosensory cortex (S1), and a force platform measured balance parameters during upright stance. RESULTS: The two-way repeated measures ANOVA results showed significant interaction in bilateral PMC/SMA activation. Moreover, patients with CLBP had significantly increased right DLPFC activation and higher sway 32 area and velocity than healthy controls during upright stance. DISCUSSION: Our results imply that PMC/SMA and DLPFC maintain standing balance. The patients with CLBP have higher cortical activity and upright stance control deficits, which may indicate that the patients with CLBP have low neural efficiency and need more motor resources to maintain balance. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9936824/ /pubmed/36816497 http://dx.doi.org/10.3389/fnhum.2023.1085831 Text en Copyright © 2023 Li, Xu, Xie, Fu, Lo, Cheng, Yang, Ge, Yu and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Li, Yan Xu, Zhaoqiang Xie, Hao Fu, Ruochen Lo, Wai Leung Ambrose Cheng, Xue Yang, Jiajia Ge, Le Yu, Quihua Wang, Chuhuai Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title | Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title_full | Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title_fullStr | Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title_full_unstemmed | Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title_short | Changes in cortical activation during upright stance in individuals with chronic low back pain: An fNIRS study |
title_sort | changes in cortical activation during upright stance in individuals with chronic low back pain: an fnirs study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9936824/ https://www.ncbi.nlm.nih.gov/pubmed/36816497 http://dx.doi.org/10.3389/fnhum.2023.1085831 |
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