Cargando…

Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion

Streptococcus pneumoniae (pneumococcus) typically colonizes the human upper airway asymptomatically but upon reaching other sites of the host body can cause an array of diseases such as pneumonia, bacteremia, otitis media, and meningitis. Be it colonization or progression to disease state, pneumococ...

Descripción completa

Detalles Bibliográficos
Autores principales: Mathew, Bijina J., Gupta, Priyal, Naaz, Tabassum, Rai, Rupal, Gupta, Sudheer, Gupta, Sudipti, Chaurasiya, Shivendra K., Purwar, Shashank, Biswas, Debasis, Vyas, Ashish Kumar, Singh, Anirudh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937060/
https://www.ncbi.nlm.nih.gov/pubmed/36816580
http://dx.doi.org/10.3389/fcimb.2023.1109449
_version_ 1784890352708091904
author Mathew, Bijina J.
Gupta, Priyal
Naaz, Tabassum
Rai, Rupal
Gupta, Sudheer
Gupta, Sudipti
Chaurasiya, Shivendra K.
Purwar, Shashank
Biswas, Debasis
Vyas, Ashish Kumar
Singh, Anirudh K.
author_facet Mathew, Bijina J.
Gupta, Priyal
Naaz, Tabassum
Rai, Rupal
Gupta, Sudheer
Gupta, Sudipti
Chaurasiya, Shivendra K.
Purwar, Shashank
Biswas, Debasis
Vyas, Ashish Kumar
Singh, Anirudh K.
author_sort Mathew, Bijina J.
collection PubMed
description Streptococcus pneumoniae (pneumococcus) typically colonizes the human upper airway asymptomatically but upon reaching other sites of the host body can cause an array of diseases such as pneumonia, bacteremia, otitis media, and meningitis. Be it colonization or progression to disease state, pneumococcus faces multiple challenges posed by host immunity ranging from complement mediated killing to inflammation driven recruitment of bactericidal cells for the containment of the pathogen. Pneumococcus has evolved several mechanisms to evade the host inflicted immune attack. The major pneumococcal virulence factor, the polysaccharide capsule helps protect the bacteria from complement mediated opsonophagocytic killing. Another important group of pneumococcal proteins which help bacteria to establish and thrive in the host environment is surface associated glycosidases. These enzymes can hydrolyze host glycans on glycoproteins, glycolipids, and glycosaminoglycans and consequently help bacteria acquire carbohydrates for growth. Many of these glycosidases directly or indirectly facilitate bacterial adherence and are known to modulate the function of host defense/immune proteins likely by removing glycans and thereby affecting their stability and/or function. Furthermore, these enzymes are known to contribute the formation of biofilms, the bacterial communities inherently resilient to antimicrobials and host immune attack. In this review, we summarize the role of these enzymes in host immune evasion.
format Online
Article
Text
id pubmed-9937060
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99370602023-02-18 Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion Mathew, Bijina J. Gupta, Priyal Naaz, Tabassum Rai, Rupal Gupta, Sudheer Gupta, Sudipti Chaurasiya, Shivendra K. Purwar, Shashank Biswas, Debasis Vyas, Ashish Kumar Singh, Anirudh K. Front Cell Infect Microbiol Cellular and Infection Microbiology Streptococcus pneumoniae (pneumococcus) typically colonizes the human upper airway asymptomatically but upon reaching other sites of the host body can cause an array of diseases such as pneumonia, bacteremia, otitis media, and meningitis. Be it colonization or progression to disease state, pneumococcus faces multiple challenges posed by host immunity ranging from complement mediated killing to inflammation driven recruitment of bactericidal cells for the containment of the pathogen. Pneumococcus has evolved several mechanisms to evade the host inflicted immune attack. The major pneumococcal virulence factor, the polysaccharide capsule helps protect the bacteria from complement mediated opsonophagocytic killing. Another important group of pneumococcal proteins which help bacteria to establish and thrive in the host environment is surface associated glycosidases. These enzymes can hydrolyze host glycans on glycoproteins, glycolipids, and glycosaminoglycans and consequently help bacteria acquire carbohydrates for growth. Many of these glycosidases directly or indirectly facilitate bacterial adherence and are known to modulate the function of host defense/immune proteins likely by removing glycans and thereby affecting their stability and/or function. Furthermore, these enzymes are known to contribute the formation of biofilms, the bacterial communities inherently resilient to antimicrobials and host immune attack. In this review, we summarize the role of these enzymes in host immune evasion. Frontiers Media S.A. 2023-02-03 /pmc/articles/PMC9937060/ /pubmed/36816580 http://dx.doi.org/10.3389/fcimb.2023.1109449 Text en Copyright © 2023 Mathew, Gupta, Naaz, Rai, Gupta, Gupta, Chaurasiya, Purwar, Biswas, Vyas and Singh https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Mathew, Bijina J.
Gupta, Priyal
Naaz, Tabassum
Rai, Rupal
Gupta, Sudheer
Gupta, Sudipti
Chaurasiya, Shivendra K.
Purwar, Shashank
Biswas, Debasis
Vyas, Ashish Kumar
Singh, Anirudh K.
Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title_full Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title_fullStr Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title_full_unstemmed Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title_short Role of Streptococcus pneumoniae extracellular glycosidases in immune evasion
title_sort role of streptococcus pneumoniae extracellular glycosidases in immune evasion
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937060/
https://www.ncbi.nlm.nih.gov/pubmed/36816580
http://dx.doi.org/10.3389/fcimb.2023.1109449
work_keys_str_mv AT mathewbijinaj roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT guptapriyal roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT naaztabassum roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT rairupal roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT guptasudheer roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT guptasudipti roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT chaurasiyashivendrak roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT purwarshashank roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT biswasdebasis roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT vyasashishkumar roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion
AT singhanirudhk roleofstreptococcuspneumoniaeextracellularglycosidasesinimmuneevasion