Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca(2+) channels drives sustained active zone potentiation

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca(2+) channels (VGCCs). While AZs can potentiate SV release in the minutes range, we lack an understanding of how AZ...

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Detalles Bibliográficos
Autores principales: Ghelani, Tina, Escher, Marc, Thomas, Ulrich, Esch, Klara, Lützkendorf, Janine, Depner, Harald, Maglione, Marta, Parutto, Pierre, Gratz, Scott, Matkovic-Rachid, Tanja, Ryglewski, Stefanie, Walter, Alexander M., Holcman, David, O‘Connor Giles, Kate, Heine, Martin, Sigrist, Stephan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937578/
https://www.ncbi.nlm.nih.gov/pubmed/36800417
http://dx.doi.org/10.1126/sciadv.ade7804

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