Alternative polyadenylation alters protein dosage by switching between intronic and 3′UTR sites

Alternative polyadenylation (APA) creates distinct transcripts from the same gene by cleaving the pre-mRNA at poly(A) sites that can lie within the 3′ untranslated region (3′UTR), introns, or exons. Most studies focus on APA within the 3′UTR; however, here, we show that CPSF6 insufficiency alters pr...

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Detalles Bibliográficos
Autores principales: de Prisco, Nicola, Ford, Caitlin, Elrod, Nathan D., Lee, Winston, Tang, Lauren C., Huang, Kai-Lieh, Lin, Ai, Ji, Ping, Jonnakuti, Venkata S., Boyle, Lia, Cabaj, Maximilian, Botta, Salvatore, Õunap, Katrin, Reinson, Karit, Wojcik, Monica H., Rosenfeld, Jill A., Bi, Weimin, Tveten, Kristian, Prescott, Trine, Gerstner, Thorsten, Schroeder, Audrey, Fong, Chin-To, George-Abraham, Jaya K., Buchanan, Catherine A., Hanson-Khan, Andrea, Bernstein, Jonathan A., Nella, Aikaterini A., Chung, Wendy K., Brandt, Vicky, Jovanovic, Marko, Targoff, Kimara L., Yalamanchili, Hari Krishna, Wagner, Eric J., Gennarino, Vincenzo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937581/
https://www.ncbi.nlm.nih.gov/pubmed/36800428
http://dx.doi.org/10.1126/sciadv.ade4814

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