The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4(+) T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

HIV-1 infection results in the activation of inflammasome that may facilitate viral spread and establishment of viral reservoirs. We evaluated the effects of the caspase-1 inhibitor VX-765 on HIV-1 infection in humanized NSG mice engrafted with human CD34(+) hematopoietic stem cells. Expression of c...

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Detalles Bibliográficos
Autores principales: Amand, Mathieu, Adams, Philipp, Schober, Rafaela, Iserentant, Gilles, Servais, Jean-Yves, Moutschen, Michel, Seguin-Devaux, Carole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937651/
https://www.ncbi.nlm.nih.gov/pubmed/36800238
http://dx.doi.org/10.7554/eLife.83207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937651/
https://www.ncbi.nlm.nih.gov/pubmed/36800238
http://dx.doi.org/10.7554/eLife.83207

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