A mouse model of human mitofusin-2-related lipodystrophy exhibits adipose-specific mitochondrial stress and reduced leptin secretion

Mitochondrial dysfunction has been reported in obesity and insulin resistance, but primary genetic mitochondrial dysfunction is generally not associated with these, arguing against a straightforward causal relationship. A rare exception, recently identified in humans, is a syndrome of lower body adi...

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Detalles Bibliográficos
Autores principales: Mann, Jake P, Duan, Xiaowen, Patel, Satish, Tábara, Luis Carlos, Scurria, Fabio, Alvarez-Guaita, Anna, Haider, Afreen, Luijten, Ineke, Page, Matthew, Protasoni, Margherita, Lim, Koini, Virtue, Sam, O'Rahilly, Stephen, Armstrong, Martin, Prudent, Julien, Semple, Robert K, Savage, David B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937658/
https://www.ncbi.nlm.nih.gov/pubmed/36722855
http://dx.doi.org/10.7554/eLife.82283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937658/
https://www.ncbi.nlm.nih.gov/pubmed/36722855
http://dx.doi.org/10.7554/eLife.82283

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