Post‐exercise hypotension in male spontaneously hypertensive rats: The issue of calculation method

In spontaneously hypertensive rats, exercise can lead to a post‐exercise decrease in blood pressure, named post‐exercise hypotension (PEH). This can be following physical training but also after a single bout of mild to moderate exercise when measured with tail‐cuff or externalized catheter methods. Our aim was to assess the PEH obtained with different calculation methods and to compare the magnitude of this effect induced by a moderate‐intensity continuous exercise or a high‐intensity intermittent exercise. Thirteen 16‐week‐old male spontaneously hypertensive rats performed two types of aerobic exercise (continuous or intermittent) on a treadmill. Arterial pressure was recorded by telemetry for 24 h which was started 3 h before physical exercise. Based on the literature, PEH was first evaluated with two different baseline values, and then with three different approaches. We observed that the identification of PEH depended on the method used to measure the rest value, and that its amplitude was also influenced by the calculation approach and the type of exercise performed. Hence, the calculation method and the amplitude of the detected PEH can significantly influence their physiological and pathophysiological inferences.