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Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis

End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of...

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Autores principales: Paré, Mathilde, Obeid, Hasan, Labrecque, Lawrence, Drapeau, Audrey, Brassard, Patrice, Agharazii, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937783/
https://www.ncbi.nlm.nih.gov/pubmed/36808481
http://dx.doi.org/10.14814/phy2.15595
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author Paré, Mathilde
Obeid, Hasan
Labrecque, Lawrence
Drapeau, Audrey
Brassard, Patrice
Agharazii, Mohsen
author_facet Paré, Mathilde
Obeid, Hasan
Labrecque, Lawrence
Drapeau, Audrey
Brassard, Patrice
Agharazii, Mohsen
author_sort Paré, Mathilde
collection PubMed
description End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of hemodialysis on pulsatile components of CBF and their relation to acute changes in arterial stiffness. In eight participants (age: 63 ± 18 years, men: 5), CBF was estimated using middle cerebral artery blood velocity (MCAv) assessed with transcranial Doppler ultrasound before, during, and after a single hemodialysis session. Brachial and central blood pressure, along with estimated aortic stiffness (eAoPWV) were measured using an oscillometric device. Arterial stiffness from heart to MCA was measured as the pulse arrival time (PAT) between electrocardiogram (ECG) and transcranial Doppler ultrasound waveforms (cerebral PAT). During hemodialysis, there was a significant reduction in mean MCAv (−3.2 cm/s, p < 0.001), and systolic MCAv (−13.0 cm/s, p < 0.001). While baseline eAoPWV (9.25 ± 0.80 m/s) did not significantly change during hemodialysis, cerebral PAT increased significantly (+0.027 , p < 0.001) and was associated with reduced pulsatile components of MCAv. This study shows that hemodialysis acutely reduces stiffness of arteries perfusing the brain along with pulsatile components of blood velocity.
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spelling pubmed-99377832023-02-18 Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis Paré, Mathilde Obeid, Hasan Labrecque, Lawrence Drapeau, Audrey Brassard, Patrice Agharazii, Mohsen Physiol Rep Original Articles End‐stage kidney disease (ESKD) is associated with increased arterial stiffness and cognitive impairment. Cognitive decline is accelerated in ESKD patients on hemodialysis and may result from repeatedly inappropriate cerebral blood flow (CBF). The aim of this study was to examine the acute effect of hemodialysis on pulsatile components of CBF and their relation to acute changes in arterial stiffness. In eight participants (age: 63 ± 18 years, men: 5), CBF was estimated using middle cerebral artery blood velocity (MCAv) assessed with transcranial Doppler ultrasound before, during, and after a single hemodialysis session. Brachial and central blood pressure, along with estimated aortic stiffness (eAoPWV) were measured using an oscillometric device. Arterial stiffness from heart to MCA was measured as the pulse arrival time (PAT) between electrocardiogram (ECG) and transcranial Doppler ultrasound waveforms (cerebral PAT). During hemodialysis, there was a significant reduction in mean MCAv (−3.2 cm/s, p < 0.001), and systolic MCAv (−13.0 cm/s, p < 0.001). While baseline eAoPWV (9.25 ± 0.80 m/s) did not significantly change during hemodialysis, cerebral PAT increased significantly (+0.027 , p < 0.001) and was associated with reduced pulsatile components of MCAv. This study shows that hemodialysis acutely reduces stiffness of arteries perfusing the brain along with pulsatile components of blood velocity. John Wiley and Sons Inc. 2023-02-17 /pmc/articles/PMC9937783/ /pubmed/36808481 http://dx.doi.org/10.14814/phy2.15595 Text en © 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Paré, Mathilde
Obeid, Hasan
Labrecque, Lawrence
Drapeau, Audrey
Brassard, Patrice
Agharazii, Mohsen
Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title_full Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title_fullStr Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title_full_unstemmed Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title_short Cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
title_sort cerebral blood flow pulsatility and cerebral artery stiffness acutely decrease during hemodialysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937783/
https://www.ncbi.nlm.nih.gov/pubmed/36808481
http://dx.doi.org/10.14814/phy2.15595
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