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Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-c...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chinese PLA General Hospital
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937815/ https://www.ncbi.nlm.nih.gov/pubmed/36820155 http://dx.doi.org/10.1016/j.joto.2022.12.005 |
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author | Tikka, Theofano Mohd Slim, Mohd Afiq Ton, Trung Sheldon, Anna Clark, Louise J. Kontorinis, Georgios |
author_facet | Tikka, Theofano Mohd Slim, Mohd Afiq Ton, Trung Sheldon, Anna Clark, Louise J. Kontorinis, Georgios |
author_sort | Tikka, Theofano |
collection | PubMed |
description | OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-control study performed in a tertiary referral center, university teaching hospital in the UK. It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period (2015–2019) compared to a gender and age matched control group. The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups. RESULTS: A total of 31 SSCD patients were recruited with a matched number of control patients. The mean Vitamin D level on the SSCD group was 44.8 nmoL/l (SD: 20.8) compared to 47.5 nmoL/l (SD: 27.4) on the control group (p = 0.702). Mean Adjusted calcium level was 2.34 mmoL/l (SD: 0.7) for SSCD compared to 2.41 mmoL/l (SD: 0.11) for controls (p = 0.01), being within normal limits for both the SSCD and the control group. CONCLUSION: Our study did not identify a link between Vitamin D levels and presence of SSCD. Normal adjusted calcium values were found in both groups. Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region. |
format | Online Article Text |
id | pubmed-9937815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Chinese PLA General Hospital |
record_format | MEDLINE/PubMed |
spelling | pubmed-99378152023-02-19 Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study Tikka, Theofano Mohd Slim, Mohd Afiq Ton, Trung Sheldon, Anna Clark, Louise J. Kontorinis, Georgios J Otol Research Article OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-control study performed in a tertiary referral center, university teaching hospital in the UK. It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period (2015–2019) compared to a gender and age matched control group. The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups. RESULTS: A total of 31 SSCD patients were recruited with a matched number of control patients. The mean Vitamin D level on the SSCD group was 44.8 nmoL/l (SD: 20.8) compared to 47.5 nmoL/l (SD: 27.4) on the control group (p = 0.702). Mean Adjusted calcium level was 2.34 mmoL/l (SD: 0.7) for SSCD compared to 2.41 mmoL/l (SD: 0.11) for controls (p = 0.01), being within normal limits for both the SSCD and the control group. CONCLUSION: Our study did not identify a link between Vitamin D levels and presence of SSCD. Normal adjusted calcium values were found in both groups. Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region. Chinese PLA General Hospital 2023-01 2022-12-26 /pmc/articles/PMC9937815/ /pubmed/36820155 http://dx.doi.org/10.1016/j.joto.2022.12.005 Text en © [copyright 2022] PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Tikka, Theofano Mohd Slim, Mohd Afiq Ton, Trung Sheldon, Anna Clark, Louise J. Kontorinis, Georgios Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title | Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title_full | Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title_fullStr | Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title_full_unstemmed | Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title_short | Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study |
title_sort | investigation of serum calcium and vitamin d levels in superior semicircular canal dehiscence syndrome: a case control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937815/ https://www.ncbi.nlm.nih.gov/pubmed/36820155 http://dx.doi.org/10.1016/j.joto.2022.12.005 |
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