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Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study

OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-c...

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Autores principales: Tikka, Theofano, Mohd Slim, Mohd Afiq, Ton, Trung, Sheldon, Anna, Clark, Louise J., Kontorinis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese PLA General Hospital 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937815/
https://www.ncbi.nlm.nih.gov/pubmed/36820155
http://dx.doi.org/10.1016/j.joto.2022.12.005
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author Tikka, Theofano
Mohd Slim, Mohd Afiq
Ton, Trung
Sheldon, Anna
Clark, Louise J.
Kontorinis, Georgios
author_facet Tikka, Theofano
Mohd Slim, Mohd Afiq
Ton, Trung
Sheldon, Anna
Clark, Louise J.
Kontorinis, Georgios
author_sort Tikka, Theofano
collection PubMed
description OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-control study performed in a tertiary referral center, university teaching hospital in the UK. It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period (2015–2019) compared to a gender and age matched control group. The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups. RESULTS: A total of 31 SSCD patients were recruited with a matched number of control patients. The mean Vitamin D level on the SSCD group was 44.8 nmoL/l (SD: 20.8) compared to 47.5 nmoL/l (SD: 27.4) on the control group (p = 0.702). Mean Adjusted calcium level was 2.34 mmoL/l (SD: 0.7) for SSCD compared to 2.41 mmoL/l (SD: 0.11) for controls (p = 0.01), being within normal limits for both the SSCD and the control group. CONCLUSION: Our study did not identify a link between Vitamin D levels and presence of SSCD. Normal adjusted calcium values were found in both groups. Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region.
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spelling pubmed-99378152023-02-19 Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study Tikka, Theofano Mohd Slim, Mohd Afiq Ton, Trung Sheldon, Anna Clark, Louise J. Kontorinis, Georgios J Otol Research Article OBJECTIVE: It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). Our aim was to analyse the adjusted calcium and vitamin D levels in SSCD patients compared to a control group. METHODS: This was a prospective case-control study performed in a tertiary referral center, university teaching hospital in the UK. It included all new patients with SSCD seen in a dedicated skull base clinic over a 5-year period (2015–2019) compared to a gender and age matched control group. The main outcome of the study was adjusted calcium and Vitamin D levels between the two groups. RESULTS: A total of 31 SSCD patients were recruited with a matched number of control patients. The mean Vitamin D level on the SSCD group was 44.8 nmoL/l (SD: 20.8) compared to 47.5 nmoL/l (SD: 27.4) on the control group (p = 0.702). Mean Adjusted calcium level was 2.34 mmoL/l (SD: 0.7) for SSCD compared to 2.41 mmoL/l (SD: 0.11) for controls (p = 0.01), being within normal limits for both the SSCD and the control group. CONCLUSION: Our study did not identify a link between Vitamin D levels and presence of SSCD. Normal adjusted calcium values were found in both groups. Despite that a statistically significant lower calcium level was found in the SSCD group which could indicate that suboptimal levels of calcium may affect the micro-environment of the otic capsule at the SSC region. Chinese PLA General Hospital 2023-01 2022-12-26 /pmc/articles/PMC9937815/ /pubmed/36820155 http://dx.doi.org/10.1016/j.joto.2022.12.005 Text en © [copyright 2022] PLA General Hospital Department of Otolaryngology Head and Neck Surgery. Production and hosting by Elsevier (Singapore) Pte Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Tikka, Theofano
Mohd Slim, Mohd Afiq
Ton, Trung
Sheldon, Anna
Clark, Louise J.
Kontorinis, Georgios
Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title_full Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title_fullStr Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title_full_unstemmed Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title_short Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study
title_sort investigation of serum calcium and vitamin d levels in superior semicircular canal dehiscence syndrome: a case control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937815/
https://www.ncbi.nlm.nih.gov/pubmed/36820155
http://dx.doi.org/10.1016/j.joto.2022.12.005
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