Structure of Helicobacter pylori dihydroneopterin aldolase suggests a fragment-based strategy for isozyme-specific inhibitor design

Dihydroneopterin aldolase (DHNA) is essential for folate biosynthesis in microorganisms. Without a counterpart in mammals, DHNA is an attractive target for antimicrobial agents. Helicobacter pylori infection occurs in human stomach of over 50% of the world population, but first-line therapies for th...

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Detalles Bibliográficos
Autores principales: Shaw, Gary X., Fan, Lixin, Cherry, Scott, Shi, Genbin, Tropea, Joseph E., Ji, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9937910/
https://www.ncbi.nlm.nih.gov/pubmed/36820301
http://dx.doi.org/10.1016/j.crstbi.2023.100095

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