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Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults

OBJECTIVE: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to i...

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Autores principales: Ortiz-Alvarez, L., Acosta, F. M., Xu, H., Sanchez-Delgado, G., Vilchez-Vargas, R., Link, A., Plaza-Díaz, J., Llamas, J. M., Gil, A., Labayen, I., Rensen, P. C. N., Ruiz, J. R., Martinez-Tellez, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938059/
https://www.ncbi.nlm.nih.gov/pubmed/36242744
http://dx.doi.org/10.1007/s40618-022-01936-x
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author Ortiz-Alvarez, L.
Acosta, F. M.
Xu, H.
Sanchez-Delgado, G.
Vilchez-Vargas, R.
Link, A.
Plaza-Díaz, J.
Llamas, J. M.
Gil, A.
Labayen, I.
Rensen, P. C. N.
Ruiz, J. R.
Martinez-Tellez, B.
author_facet Ortiz-Alvarez, L.
Acosta, F. M.
Xu, H.
Sanchez-Delgado, G.
Vilchez-Vargas, R.
Link, A.
Plaza-Díaz, J.
Llamas, J. M.
Gil, A.
Labayen, I.
Rensen, P. C. N.
Ruiz, J. R.
Martinez-Tellez, B.
author_sort Ortiz-Alvarez, L.
collection PubMed
description OBJECTIVE: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to investigate the association of fecal microbiota composition with BAT volume and activity and mean radiodensity in young adults. METHODS: 82 young adults (58 women, 21.8 ± 2.2 years old) participated in this cross-sectional study. DNA was extracted from fecal samples and 16S rRNA sequencing was performed to analyse the fecal microbiota composition. BAT was determined via a static (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography scan (PET/CT) after a 2 h personalized cooling protocol. (18)F-FDG uptake was also quantified in white adipose tissue (WAT) and skeletal muscles. RESULTS: The relative abundance of Akkermansia, Lachnospiraceae sp. and Ruminococcus genera was negatively correlated with BAT volume, BAT SUVmean and BAT SUVpeak (all rho ≤ − 0.232, P ≤ 0.027), whereas the relative abundance of Bifidobacterium genus was positively correlated with BAT SUVmean and BAT SUVpeak (all rho ≥ 0.262, P ≤ 0.012). On the other hand, the relative abundance of Sutterellaceae and Bifidobacteriaceae families was positively correlated with (18)F-FDG uptake by WAT and skeletal muscles (all rho ≥ 0.213, P ≤ 0.042). All the analyses were adjusted for the PET/CT scan date as a proxy of seasonality. CONCLUSION: Our results suggest that fecal microbiota composition is involved in the regulation of BAT and glucose uptake by other tissues in young adults. Further studies are needed to confirm these findings. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov no. NCT02365129 (registered 18 February 2015). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-022-01936-x.
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spelling pubmed-99380592023-02-19 Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults Ortiz-Alvarez, L. Acosta, F. M. Xu, H. Sanchez-Delgado, G. Vilchez-Vargas, R. Link, A. Plaza-Díaz, J. Llamas, J. M. Gil, A. Labayen, I. Rensen, P. C. N. Ruiz, J. R. Martinez-Tellez, B. J Endocrinol Invest Original Article OBJECTIVE: Human brown adipose tissue (BAT) has gained considerable attention as a potential therapeutic target for obesity and its related cardiometabolic diseases; however, whether the gut microbiota might be an efficient stimulus to activate BAT metabolism remains to be ascertained. We aimed to investigate the association of fecal microbiota composition with BAT volume and activity and mean radiodensity in young adults. METHODS: 82 young adults (58 women, 21.8 ± 2.2 years old) participated in this cross-sectional study. DNA was extracted from fecal samples and 16S rRNA sequencing was performed to analyse the fecal microbiota composition. BAT was determined via a static (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography-computed tomography scan (PET/CT) after a 2 h personalized cooling protocol. (18)F-FDG uptake was also quantified in white adipose tissue (WAT) and skeletal muscles. RESULTS: The relative abundance of Akkermansia, Lachnospiraceae sp. and Ruminococcus genera was negatively correlated with BAT volume, BAT SUVmean and BAT SUVpeak (all rho ≤ − 0.232, P ≤ 0.027), whereas the relative abundance of Bifidobacterium genus was positively correlated with BAT SUVmean and BAT SUVpeak (all rho ≥ 0.262, P ≤ 0.012). On the other hand, the relative abundance of Sutterellaceae and Bifidobacteriaceae families was positively correlated with (18)F-FDG uptake by WAT and skeletal muscles (all rho ≥ 0.213, P ≤ 0.042). All the analyses were adjusted for the PET/CT scan date as a proxy of seasonality. CONCLUSION: Our results suggest that fecal microbiota composition is involved in the regulation of BAT and glucose uptake by other tissues in young adults. Further studies are needed to confirm these findings. CLINICAL TRIAL INFORMATION: ClinicalTrials.gov no. NCT02365129 (registered 18 February 2015). SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-022-01936-x. Springer International Publishing 2022-10-15 2023 /pmc/articles/PMC9938059/ /pubmed/36242744 http://dx.doi.org/10.1007/s40618-022-01936-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Ortiz-Alvarez, L.
Acosta, F. M.
Xu, H.
Sanchez-Delgado, G.
Vilchez-Vargas, R.
Link, A.
Plaza-Díaz, J.
Llamas, J. M.
Gil, A.
Labayen, I.
Rensen, P. C. N.
Ruiz, J. R.
Martinez-Tellez, B.
Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title_full Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title_fullStr Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title_full_unstemmed Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title_short Fecal microbiota composition is related to brown adipose tissue (18)F-fluorodeoxyglucose uptake in young adults
title_sort fecal microbiota composition is related to brown adipose tissue (18)f-fluorodeoxyglucose uptake in young adults
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938059/
https://www.ncbi.nlm.nih.gov/pubmed/36242744
http://dx.doi.org/10.1007/s40618-022-01936-x
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