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Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?

AIM: To assess whether serum thymidine kinase 1 (STK1p), CEA and CA19.9 can be used as prognostic biomarkers in the primary tumor location (PTL) of colorectal carcinoma (CRC). Additional clinical factors of TNM stage, pathological grade, age and sex were also included. METHODS: STK1p was determined...

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Autores principales: Fang, Yujing, Skog, Sven, Ou, Qingjian, Chen, Zhiheng, Liu, Senbo, Hei, Ailian, Li, Jin, Zhou, Ji, He, Ellen, Wan, Desen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938097/
https://www.ncbi.nlm.nih.gov/pubmed/36800051
http://dx.doi.org/10.1007/s12672-023-00614-5
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author Fang, Yujing
Skog, Sven
Ou, Qingjian
Chen, Zhiheng
Liu, Senbo
Hei, Ailian
Li, Jin
Zhou, Ji
He, Ellen
Wan, Desen
author_facet Fang, Yujing
Skog, Sven
Ou, Qingjian
Chen, Zhiheng
Liu, Senbo
Hei, Ailian
Li, Jin
Zhou, Ji
He, Ellen
Wan, Desen
author_sort Fang, Yujing
collection PubMed
description AIM: To assess whether serum thymidine kinase 1 (STK1p), CEA and CA19.9 can be used as prognostic biomarkers in the primary tumor location (PTL) of colorectal carcinoma (CRC). Additional clinical factors of TNM stage, pathological grade, age and sex were also included. METHODS: STK1p was determined by an ECL-dot-blot assay, and CEA/CA19.9 was determined by an automatic electrochemiluminescence analyzer in a retrospective presurgery of right-colon carcinoma (R-CC, n = 90), left-colon carcinoma (L-CC, n = 128) and rectal carcinoma (RC, n = 270). Prognostic factors were evaluated by COX and overall survival (OS). RESULTS: The multivariate-COX and OS in relation to the prognostic factors of PTL in CRC were different and complex. An elevated STK1p value was significantly associated with poor OS in RC (P = 0.002) and L-CC (P = 0.037) but not in R-CC (P > 0.05). Elevated CEA (P≈.000) and CA19.9 (P≈.000) were significantly associated with poor OS in RC but not in L-CC and R-CC. Multivariate-COX showed that STK1p (P = 0.02, HR = 1.779, 95%CI 1.30–7.582), CEA (P = 0.001, HR = 2.052, 95%CI 1.320–3.189), CA19.9 (P≈.000, HR = 2.574, 95%CI 1.592–4.162) and TNM-stage (P≈.000, HR = 2.368, 95%CI 1.518–3.694) were independent prognostic factors in RC, while TNM-stage was an independent prognostic factor only in R-CC (P = 0.011, HR = 3.139, 95% CI 1.30–7.582) and L-CC (P≈.000, HR = 4.168, 95%CI 1.980–8.852). Moreover, elevated STK1p was significantly more sensitive (P < .001) for predicting mortality than CEA and CA19.9. No correlation was found between STK1p, CEA or AFP. CONCLUSION: Combining TNM stage and suitable biomarkers, STK1p provides further reliable information on the survival of PTL of CRC.
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spelling pubmed-99380972023-02-19 Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas? Fang, Yujing Skog, Sven Ou, Qingjian Chen, Zhiheng Liu, Senbo Hei, Ailian Li, Jin Zhou, Ji He, Ellen Wan, Desen Discov Oncol Research AIM: To assess whether serum thymidine kinase 1 (STK1p), CEA and CA19.9 can be used as prognostic biomarkers in the primary tumor location (PTL) of colorectal carcinoma (CRC). Additional clinical factors of TNM stage, pathological grade, age and sex were also included. METHODS: STK1p was determined by an ECL-dot-blot assay, and CEA/CA19.9 was determined by an automatic electrochemiluminescence analyzer in a retrospective presurgery of right-colon carcinoma (R-CC, n = 90), left-colon carcinoma (L-CC, n = 128) and rectal carcinoma (RC, n = 270). Prognostic factors were evaluated by COX and overall survival (OS). RESULTS: The multivariate-COX and OS in relation to the prognostic factors of PTL in CRC were different and complex. An elevated STK1p value was significantly associated with poor OS in RC (P = 0.002) and L-CC (P = 0.037) but not in R-CC (P > 0.05). Elevated CEA (P≈.000) and CA19.9 (P≈.000) were significantly associated with poor OS in RC but not in L-CC and R-CC. Multivariate-COX showed that STK1p (P = 0.02, HR = 1.779, 95%CI 1.30–7.582), CEA (P = 0.001, HR = 2.052, 95%CI 1.320–3.189), CA19.9 (P≈.000, HR = 2.574, 95%CI 1.592–4.162) and TNM-stage (P≈.000, HR = 2.368, 95%CI 1.518–3.694) were independent prognostic factors in RC, while TNM-stage was an independent prognostic factor only in R-CC (P = 0.011, HR = 3.139, 95% CI 1.30–7.582) and L-CC (P≈.000, HR = 4.168, 95%CI 1.980–8.852). Moreover, elevated STK1p was significantly more sensitive (P < .001) for predicting mortality than CEA and CA19.9. No correlation was found between STK1p, CEA or AFP. CONCLUSION: Combining TNM stage and suitable biomarkers, STK1p provides further reliable information on the survival of PTL of CRC. Springer US 2023-02-17 /pmc/articles/PMC9938097/ /pubmed/36800051 http://dx.doi.org/10.1007/s12672-023-00614-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Fang, Yujing
Skog, Sven
Ou, Qingjian
Chen, Zhiheng
Liu, Senbo
Hei, Ailian
Li, Jin
Zhou, Ji
He, Ellen
Wan, Desen
Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title_full Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title_fullStr Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title_full_unstemmed Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title_short Is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
title_sort is serum thymidine kinase 1 a prognostic biomarker in primary tumor location of colorectal carcinomas?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938097/
https://www.ncbi.nlm.nih.gov/pubmed/36800051
http://dx.doi.org/10.1007/s12672-023-00614-5
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