Modulation of AMPK/ TET2/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development

Obesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which is a substrate of AMPK, thereby dysregulating 5-hydroxymethylcytosine (5-hmC). However, the role played by this novel pathway in the development o...

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Detalles Bibliográficos
Autores principales: Kon, Takashi, Sasaki, Yu, Abe, Yasuhiko, Onozato, Yusuke, Yagi, Makoto, Mizumoto, Naoko, Sakai, Takayuki, Umehara, Matsuki, Ito, Minami, Nakamura, Shuhei, Goto, Hiroki, Ueno, Yoshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938119/
https://www.ncbi.nlm.nih.gov/pubmed/36806702
http://dx.doi.org/10.1038/s41598-023-29958-2

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