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Widespread perturbation of ETS factor binding sites in cancer

Although >90% of somatic mutations reside in non-coding regions, few have been reported as cancer drivers. To predict driver non-coding variants (NCVs), we present a transcription factor (TF)-aware burden test based on a model of coherent TF function in promoters. We apply this test to NCVs from...

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Detalles Bibliográficos
Autores principales:	Carrasco Pro, Sebastian, Hook, Heather, Bray, David, Berenzy, Daniel, Moyer, Devlin, Yin, Meimei, Labadorf, Adam Thomas, Tewhey, Ryan, Siggers, Trevor, Fuxman Bass, Juan Ignacio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938127/ https://www.ncbi.nlm.nih.gov/pubmed/36808133 http://dx.doi.org/10.1038/s41467-023-36535-8

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