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Tumour-infiltrating lymphocytes: from prognosis to treatment selection
Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent o...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938191/ https://www.ncbi.nlm.nih.gov/pubmed/36564565 http://dx.doi.org/10.1038/s41416-022-02119-4 |
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author | Brummel, Koen Eerkens, Anneke L. de Bruyn, Marco Nijman, Hans W. |
author_facet | Brummel, Koen Eerkens, Anneke L. de Bruyn, Marco Nijman, Hans W. |
author_sort | Brummel, Koen |
collection | PubMed |
description | Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials. |
format | Online Article Text |
id | pubmed-9938191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99381912023-02-19 Tumour-infiltrating lymphocytes: from prognosis to treatment selection Brummel, Koen Eerkens, Anneke L. de Bruyn, Marco Nijman, Hans W. Br J Cancer Review Article Tumour-infiltrating lymphocytes (TILs) are considered crucial in anti-tumour immunity. Accordingly, the presence of TILs contains prognostic and predictive value. In 2011, we performed a systematic review and meta-analysis on the prognostic value of TILs across cancer types. Since then, the advent of immune checkpoint blockade (ICB) has renewed interest in the analysis of TILs. In this review, we first describe how our understanding of the prognostic value of TIL has changed over the last decade. New insights on novel TIL subsets are discussed and give a broader view on the prognostic effect of TILs in cancer. Apart from prognostic value, evidence on the predictive significance of TILs in the immune therapy era are discussed, as well as new techniques, such as machine learning that strive to incorporate these predictive capacities within clinical trials. Nature Publishing Group UK 2022-12-23 2023-02-02 /pmc/articles/PMC9938191/ /pubmed/36564565 http://dx.doi.org/10.1038/s41416-022-02119-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Brummel, Koen Eerkens, Anneke L. de Bruyn, Marco Nijman, Hans W. Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title | Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title_full | Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title_fullStr | Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title_full_unstemmed | Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title_short | Tumour-infiltrating lymphocytes: from prognosis to treatment selection |
title_sort | tumour-infiltrating lymphocytes: from prognosis to treatment selection |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938191/ https://www.ncbi.nlm.nih.gov/pubmed/36564565 http://dx.doi.org/10.1038/s41416-022-02119-4 |
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